Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1887-1890
XIAO Yong, JIN Shaowei, DONG Zhen, WANG Tianshu. Observation on the effect of Shen Yuanliang's prescription in treating CAG patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1887-1890. doi: 10.16766/j.cnki.issn.1674-4152.003757
Citation: XIAO Yong, JIN Shaowei, DONG Zhen, WANG Tianshu. Observation on the effect of Shen Yuanliang's prescription in treating CAG patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1887-1890. doi: 10.16766/j.cnki.issn.1674-4152.003757
shu

Observation on the effect of Shen Yuanliang's prescription in treating CAG patients

doi: 10.16766/j.cnki.issn.1674-4152.003757
  • 1.

    General Practice Department, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, China

Funds:

 2023ZR135

  • Received Date: 2024-05-22
    Available Online: 2024-12-31
    Abstract
  •   Objective  To explore the improvement effect and mechanism of Shen Yuanliang's prescription in treating chronic atrophic gastritis (CAG) on gastric mucosal lesions.  Methods  A total of 105 CAG patients admitted to Shaoxing Hospital of Traditional Chinese Medicine from September 2020 to September 2023 were selected and randomly divided into Group A (53 cases) and Group B (52 cases) using a random number table method. Patients in Group B were treated with Western medicine, while patients in Group A were administered Shen Yuanliang's traditional Chinese medicine prescription in addition to the Western medicine treatment received by Group B. Before and after treatment, the patients' gastric mucosal histopathology scores, serum fibroblast growth factor 23 (FGF-23), cholinesterase (S-ChE), pepsinogen Ⅰ (PG Ⅰ), pepsinogen Ⅱ (PG Ⅱ), changes in traditional Chinese medicine syndrome scores, and clinical effects were compared.  Results  After treatment, the serum FGF-23 level in Group A was lower than that in Group B, while the serum S-ChE and PG Ⅰ levels were higher than those in Group B, with statistically significant differences (P < 0.05). Group A had lower scores for epigastric distention and pain, nausea and vomiting, qi stagnation and indigestion, belching, and acid reflux than Group B (P < 0.05). After treatment, Group A had lower scores for gastric mucosal atrophy, chronic inflammation, intestinal metaplasia, and intestinal dysplasia than Group B (P < 0.05). There were 32 cases of marked effectiveness, 18 cases of effectiveness, and 3 cases of ineffectiveness in Group A, while Group B had 20 cases of marked effectiveness, 24 cases of effectiveness, and 8 cases of ineffectiveness. The overall therapeutic effect was better in Group A than in Group B (Z=-2.402, P < 0.05).  Conclusion  The treatment of CAG patients with Shen Yuanliang's prescription can improve the gastric mucosal histopathological features more effectively, improve the levels of S-ChE, FGF-23, PG Ⅰ, and PG Ⅱ in serum and clinical symptoms, and the overall clinical effect is better.

     

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