Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1895-1898
LI Mingzhu, WEN Ronghua, YUE Qing. Expression of Sestrin2 in serum of neonatal hypoxic-ischemic encephalopathy and its correlation with disease severity[J]. Chinese Journal of General Practice, 2024, 22(11): 1895-1898. doi: 10.16766/j.cnki.issn.1674-4152.003759
Citation: LI Mingzhu, WEN Ronghua, YUE Qing. Expression of Sestrin2 in serum of neonatal hypoxic-ischemic encephalopathy and its correlation with disease severity[J]. Chinese Journal of General Practice, 2024, 22(11): 1895-1898. doi: 10.16766/j.cnki.issn.1674-4152.003759
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Expression of Sestrin2 in serum of neonatal hypoxic-ischemic encephalopathy and its correlation with disease severity

doi: 10.16766/j.cnki.issn.1674-4152.003759
  • 1.

    Department of Neonatology, Linfen People's Hospital, Linfen, Shanxi 041000, China

Funds:

 2020142

  • Received Date: 2023-12-25
    Available Online: 2024-12-31
    Abstract
  •   Objective  To investigate the expression of serum Sestrin2 in neonates with hypoxic ischemic encephalopathy (HIE) and its clinical significance in order to improve the diagnostic accuracy and prognosis of HIE.  Methods  A total of 78 HIE children admitted to Linfen People's Hospital from June 2020 to April 2023 were selected as HIE group. They were divided into mild, moderate, and severe HIE subgroups according to the severity of the disease. Additionally, 30 healthy newborns born in our hospital during the same period were selected as the control group. The 5-min Apgar score and neonatal behavioral neurological assessment (NBNA) score of all newborns were recorded. Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), and Sestrin2 were detected in all newborns.  Results  The serum levels of Sestrin2 in the HIE group were higher than those in the control group (P < 0.05). Within the HIE group, the levels of serum Sestrin2 increased progressively from mild to severe HIE (P < 0.05). Pearson correlation analysis showed that serum Sestrin2 levels in HIE patients were positively correlated with serum MDA levels and negatively correlated with 5-minute Apgar score, NBNA score, and serum SOD level (P < 0.05). The receiver operating characteristic curve (ROC) analysis showed that serum Sestrin2 had a certain auxiliary diagnostic value for HIE, with an area under the curve of 0.818 (95% CI: 0.732-0.886). At a cut-off value of 8.25 ng/mL, the sensitivity was 66.67% (52/78), the specificity was 93.33% (28/30), and the Youden's J statistic was 0.600.  Conclusion  The expression of Sestrin2 in the serum of neonates with HIE is abnormally high and closely related to the severity of the disease and the degree of oxidative stress of the neonates. The detection of Sestrin2 in the serum is helpful for the auxiliary diagnosis of HIE.

     

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    • References(20)
  • [1]
    VICTOR S, ROCHA-FERREIRA E, RAHIM A, et al. New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy[J]. Eur J Pediatr, 2022, 181(3): 875-887. doi: 10.1007/s00431-021-04320-8
    [2]
    PAPPAS A, MILANO G, CHALAK L F. Hypoxic-ischemic encephalopathy: changing outcomes across the spectrum[J]. Clin Perinatol, 2023, 50(1): 31-52. doi: 10.1016/j.clp.2022.11.007
    [3]
    GRECO P, NENCINI G, PIVA I, et al. Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future[J]. Acta Neurol Belg, 2020, 120(2): 277-288. doi: 10.1007/s13760-020-01308-3
    [4]
    何春, 陈礼娟, 黄凤枚, 等. 干预性护理措施对有创通气下行全身亚低温治疗的重度缺氧缺血性脑病患儿的临床效果[J]. 中华全科医学, 2023, 21(4): 717-720. doi: 10.16766/j.cnki.issn.1674-4152.002967

    HE C, CHEN L J, HUANG F M, et al. Clinical effect of interventional nursing measures for children with severe hypoxic ischemic encephalopathy treated with systemic mild hypothermia under invasive ventilation[J]. Chinese Journal of General Practice, 2023, 21(4): 717-720. doi: 10.16766/j.cnki.issn.1674-4152.002967
    [5]
    李福军, 姜涛, 郭力甲, 等. Sestrin2通过Nrf2/xCT途径减轻七氟醚诱导的HT22细胞铁死亡研究[J]. 中华全科医学, 2021, 19(6): 917-920, 1068. doi: 10.16766/j.cnki.issn.1674-4152.001949

    LI F J, JIANG T, GUO L J, et al. Sestrin 2 extenuates neuronal ferroptosis induced by sevoflurane through the Nrf2/xCT pathway[J]. Chinese Journal of General Practice, 2021, 19(6): 917-920. doi: 10.16766/j.cnki.issn.1674-4152.001949
    [6]
    滕丽峰, 陈茜茜, 叶丛, 等. 血清Sestrin2在急性ST段抬高型心肌梗死中的表达及其与缺血再灌注损伤的关系[J]. 天津医药, 2023, 51(3): 303-306.

    TENG L F, CHEN Q Q, YE C, et al. Expression of serum Sestrin2 in acute ST-segment elevation myocardial infarction and its relationship with ischemia-reperfusion injury[J]. Tianjin Medical Journal, 2023, 51(3): 303-306.
    [7]
    SHI X D, XU L, DOYCHEVA D M, et al. Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups[J]. J Cereb Blood Flow Metab, 2017, 37(4): 1447-1460. doi: 10.1177/0271678X16656201
    [8]
    中华医学会儿科学分会新生儿学组. 新生儿缺氧缺血性脑病诊断标准[J]. 中华儿科杂志, 2005, 43(8): 584.

    Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association. Diagnostic criteria for neonatal hypoxic-ischemic encephalopathy[J]. Chinese Journal of Pediatrics, 2005, 43(8): 584.
    [9]
    苏猛, 张星, 张雷. NLR、NBNA评分在新生儿窒息中的临床应用价值[J]. 国际检验医学杂志, 2020, 41(12): 1505-1508.

    SU M, ZHANG X, ZHANG L. Clinical value of NLR and NBNA score in neonatal asphyxia[J]. International Journal of Laboratory Medicine, 2020, 41(12): 1505-1508.
    [10]
    PEDROZA-GARCÍA K A, CALDERÓN-VALLEJO D, QUINTANAR J L. Neonatal hypoxic-ischemic encephalopathy: perspectives of neuroprotective and neuroregenerative treatments[J]. Neuropediatrics, 2022, 53(6): 402-417.
    [11]
    中华医学会儿科学分会新生儿学组, 中华儿科杂志编辑委员会. 亚低温治疗新生儿缺氧缺血性脑病专家共识(2022)[J]. 中华儿科杂志, 2022, 60(10): 983-989.

    Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association, Editorial Committee of Chinese Journal of Pediatrics. Expert consensus on therapeutic hypothermia in neonates with hypoxic ischemic encephalopathy (2022)[J]. Chinese Journal of Pediatrics, 2022, 60(10): 983-989.
    [12]
    CARAMELO I, COELHO M, ROSADO M, et al. Biomarkers of hypoxic-ischemic encephalopathy: a systematic review[J]. World J Pediatr, 2023, 19(6): 505-548.
    [13]
    张晶, 谷丽彩, 李燕燕, 等. 依达拉奉对缺氧缺血性脑病大鼠脑组织MMP-9、MMP-3、SOD、MDA表达的影响[J]. 药物生物技术, 2021, 28(4): 381-384.

    ZHANG J, GU L C, LI Y Y, et al. Effects of edaravone on the expression of MMP-9, MMP-3, SOD and MDA in brain tissue of rats with hypoxic-ischemic brain damage[J]. Chinese Journal of Pharmaceutical Biotechnology, 2021, 28(4): 381-384.
    [14]
    ZAHID M A, ABDELSALAM S S, RAÏQ H, et al. Sestrin2 as a protective shield against cardiovascular disease[J]. Int J Mol Sci, 2023, 24(5): 4880. DOI: 10.3390/ijms24054880.
    [15]
    PAN C Y, CHEN Z L, LI C, et al. Sestrin2 as a gatekeeper of cellular homeostasis: physiological effects for the regulation of hypoxia-related diseases[J]. J Cell Mol Med, 2021, 25(12): 5341-5350.
    [16]
    王迪, 啜红斐. 血清Sestrin2水平与急性脑梗死患者氧化应激反应及早期神经功能恶化的关系[J]. 实用临床医药杂志, 2022, 26(6): 14-17, 22.

    WANG D, CHUO H F. Correlations of serum Sestrin2 level with oxidative stress response and early deterioration of neurological function in patients with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2022, 26(6): 14-17, 22.
    [17]
    刘英存, 李飞, 黄毅, 等. Sestrin2蛋白通过Nrf2/HO-1信号通路保护大鼠心肌细胞缺氧复氧损伤[J]. 第三军医大学学报, 2020, 42(15): 1536-1542.

    LIU Y C, LI F, HUANG Y, et al. Sestrin2 protects rat cardiomyocytes from hypoxia-reoxygenation injury through Nrf2/HO-1 signaling pathway[J]. Journal of third military medical university, 2020, 42(15): 1536-1542.
    [18]
    MONACO-BROWN M, MUNSHI U, HORGAN M J, et al. Association of maternal obesity and neonatal hypoxic-ischemic encephalopathy[J]. Front Pediatr, 2022, 10: 850654. DOI: 10.3389/fped.2022.850654.
    [19]
    WANG J N, LI J, YIN X P, et al. The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy[J]. Curr Neurovasc Res, 2021, 18(3): 307-313.
    [20]
    ZHENG Y H, LI L Y, CHEN B W, et al. Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-κB signaling pathway[J]. Cell Commun Signal, 2022, 20(1): 84. DOI: 10.1186/s12964-022-00860-0.
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