Volume 22 Issue 12
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ZHENG Qian, YU Caiyao, LI Haoyun, FENG Zhanhui. Systemic lupus erythematosus and myasthenia gravis: a bidirectional Mendelian randomization study[J]. Chinese Journal of General Practice, 2024, 22(12): 2020-2024. doi: 10.16766/j.cnki.issn.1674-4152.003788
Citation: ZHENG Qian, YU Caiyao, LI Haoyun, FENG Zhanhui. Systemic lupus erythematosus and myasthenia gravis: a bidirectional Mendelian randomization study[J]. Chinese Journal of General Practice, 2024, 22(12): 2020-2024. doi: 10.16766/j.cnki.issn.1674-4152.003788
shu

Systemic lupus erythematosus and myasthenia gravis: a bidirectional Mendelian randomization study

doi: 10.16766/j.cnki.issn.1674-4152.003788

  • Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China

Funds:

 82360266

  • Received Date: 2024-08-17
    Available Online: 2025-01-20
    Abstract
  •   Objective  Studies have shown that systemic lupus erythematosus (SLE) and Myasthenia gravis (MG) may have concurrent onset clinically. This study aims to explore the potential causal relationship between SLE and MG using a bidirectional Mendelian randomization study to provide a basis for clinical prevention and treatment.  Methods  Genetic data closely related to SLE and MG were extracted from the summary database of genome-wide association studies (GWAS) as instrumental variables, and the extracted data were all from European samples. MR analysis was conducted using IVW, MR-Egger regression, and WME. The causal relationship between SLE and MG was evaluated by the OR value and 95% CI. The MR-Egger intercept method was used to detect horizontal pleiotropy, and the leave-one-out method was used for sensitivity analysis.  Results  SLE was associated with an increased risk of MG (OR=1.698, 95% CI: 1.329-2.171, P<0.001); similarly, MG was associated with an increased risk of SLE (OR=1.527, 95% CI: 1.248-1.869, P<0.001). There was no heterogeneity in the two-way results and no horizontal pleiotropy. The sensitivity analysis results of the leave-one-out method were stable.  Conclusion  There is a bidirectional causal relationship between SLE and MG. SLE patients will increase the risk of MG onset, and MG will also increase the risk of SLE onset.

     

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