Volume 22 Issue 12
Dec.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(12): 2029-2032
CHENG Cui, GUO Suyang, ZHANG Huihui, WEI Li, LI Yan, WANG Lihua, JIANG Hao. Expression of cuprotosis-related gene LIPT1 in endometrial cancer and its clinical significance[J]. Chinese Journal of General Practice, 2024, 22(12): 2029-2032. doi: 10.16766/j.cnki.issn.1674-4152.003790
Citation: CHENG Cui, GUO Suyang, ZHANG Huihui, WEI Li, LI Yan, WANG Lihua, JIANG Hao. Expression of cuprotosis-related gene LIPT1 in endometrial cancer and its clinical significance[J]. Chinese Journal of General Practice, 2024, 22(12): 2029-2032. doi: 10.16766/j.cnki.issn.1674-4152.003790
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Expression of cuprotosis-related gene LIPT1 in endometrial cancer and its clinical significance

doi: 10.16766/j.cnki.issn.1674-4152.003790
  • 1.

    Department of Gynecologic Oncology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2023AH052012

 2021byzd146

  • Received Date: 2024-01-25
    Available Online: 2025-01-20
    Abstract
  •   Objective  Lipoyltransferase 1 (LIPT1) is one of the key genes for copper death, and LIPT1 expression and its clinical significance were analysed in endometrial cancer (UCEC) using the TCGA database and clinical samples.  Methods  The immunohistochemical experimental results of TCGA-UCEC samples and tissue specimens of 59 UCEC patients were employed to substantiate the discrepancies in LIPT1 mRNA and protein expression and their correlation with clinical characteristics, as well as prognostic analyses. Subsequently, the relationship between LIPT1 and immune cells and immune checkpoints was subjected to analysis.  Results  The results showed that the expression of LIPT1 gene in cancer tissues was significantly lower than that in normal tissues (P < 0.001), and it was highly expressed in the adjacent normal tissues (P < 0.001). Immunohistochemical experiments also showed that the positive expression of LIPT1 protein was lower in cancerous tissues [40.68% (24/59)] than in paracancerous tissues [76.92% (20/26), χ2=9.495, P=0.002]. The differences in age (P=0.025), pathological grade (P=0.004) and pathological type (P < 0.001) of patients with different LIPT1 expression levels were statistically significant. The analysis of the clinical samples showed that the differences in age and pathological grading of patients with different LIPT1 expression levels were statistically significant (P < 0.05). Patients with UCEC who exhibited high LIPT1 expression exhibited poorer OS, DSS and PFI, which were identified as independent poor prognostic factors for OS. LIPT1 expression was found to be correlated with CD8+ T-cells, macrophages and neutrophils (P < 0.05). The expression of LIPT1 was correlated with PD-L1 (P < 0.01), but not correlated with PD-1 or CTLA-4.  Conclusion  LIPT1 is expressed at low levels in UCEC, but high levels are associated with poor prognosis and may be related to cancer cell immune escape. It is anticipated that this will become a new therapeutic target for UCEC.

     

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