Risk factors of extubation failure in premature infants with respiratory distress syndrome born before 32 weeks of gestation

WANG Yue; CHEN Xin; ZHANG Zhen; LI Ru'na

doi:10.16766/j.cnki.issn.1674-4152.003802

Volume 22 Issue 12

Dec. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(12): 2080-2083

WANG Yue, CHEN Xin, ZHANG Zhen, LI Ru'na. Risk factors of extubation failure in premature infants with respiratory distress syndrome born before 32 weeks of gestation[J]. Chinese Journal of General Practice, 2024, 22(12): 2080-2083. doi: 10.16766/j.cnki.issn.1674-4152.003802

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WANG Yue, CHEN Xin, ZHANG Zhen, LI Ru'na. Risk factors of extubation failure in premature infants with respiratory distress syndrome born before 32 weeks of gestation[J]. Chinese Journal of General Practice, 2024, 22(12): 2080-2083. doi: 10.16766/j.cnki.issn.1674-4152.003802

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Risk factors of extubation failure in premature infants with respiratory distress syndrome born before 32 weeks of gestation

doi: 10.16766/j.cnki.issn.1674-4152.003802

Department of Neonatology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

KJ2021A0800

2022byflc009

Received Date: 2024-05-11
Available Online: 2025-01-20

Abstract

Abstract

Objective To study the clinical characteristics of premature infants with respiratory distress syndrome (RDS) by tracheal intubation mechanical ventilation, analyze the risk factors and adverse outcomes of extubation failure, and provide evidence for its prevention. Methods The clinical data from preterm infants (< 32 weeks gestational age) admitted to Neonatal Intensive Care Unit (NICU) of the First Affiliated Hospital of Bengbu Medical University from June 2017 to December 2022 were reviewed and analyzed. According to the outcome of tracheal intubation and extubation, they were divided into a successful group and a failed group. The risk factors for extubation failure were analyzed, and the clinical progression and outcomes of the two groups were compared. Results A total of 153 premature infants with RDS were included, with 128 infants in the successful extubation group and 25 infants (16.3%) in the failed extubation group. Logistic regression analysis identified the following significant risk factors for extubation failure: low birth weight (OR=9.215, 95% CI: 1.153-73.611, P < 0.05), and low 5-minute Apgar score (OR=2.769, 95% CI: 1.681-4.563, P < 0.05), no caffeine use (OR=46.353, 95% CI: 3.489-615.792, P < 0.05), high PaCO₂ before extubation (OR=0.871, 95% CI: 0.809-0.938, P < 0.05), and low PaO₂ before extubation (OR=1.058, 95% CI: 1.018-1.101, P < 0.05). The rates of death or abandonment of treatment, ventilator-associated pneumonia (VAP), and bronchopulmonary dysplasia (BPD) were higher in the failed group (P < 0.05). Additionally, the failed group required longer oxygen therapy compared to the successful group (P < 0.05). Conclusion Lower birth weight, lower 5-minute Apgar score, no caffeine use, elevated PaCO₂, and reduced PaO₂ are significant predictors of extubation failure in premature infants with RDS. Extubation failure increases the risk of death and adverse outcomes in these infants.
- Tracheal intubation,
- Extubation failure,
- Preterm infant

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Risk factors of extubation failure in premature infants with respiratory distress syndrome born before 32 weeks of gestation

doi: 10.16766/j.cnki.issn.1674-4152.003802

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Risk factors of extubation failure in premature infants with respiratory distress syndrome born before 32 weeks of gestation

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