Volume 23 Issue 1
Jan.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(1): 36-39
BAO Hongdan, ZHOU Yafen, SHI Qiongyao, GUO Jingyi, ZHANG Zhenlin, GAO Chao. Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults[J]. Chinese Journal of General Practice, 2025, 23(1): 36-39. doi: 10.16766/j.cnki.issn.1674-4152.003830
Citation: BAO Hongdan, ZHOU Yafen, SHI Qiongyao, GUO Jingyi, ZHANG Zhenlin, GAO Chao. Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults[J]. Chinese Journal of General Practice, 2025, 23(1): 36-39. doi: 10.16766/j.cnki.issn.1674-4152.003830
shu

Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults

doi: 10.16766/j.cnki.issn.1674-4152.003830
  • 1.

    Department of Endocrinology, Ningbo Fourth People' s Hospital, Ningbo, Zhejiang 315700, China

Funds:

 81900808

  • Received Date: 2024-02-01
    Available Online: 2025-02-13
    Abstract
  •   Objective  To investigate the level and deficiency of 25-hydroxyvitamin D [25(OH)D] in adults living in Xiangshan County, Ningbo City, and to analyze the association between 25(OH)D levels with bone turnover markers (BTMs) and bone mineral density (BMD).  Methods  From August to November 2020, 3 117 volunteers were recruited from Xiangshan County, Ningbo City, including 1 122 males and 1 995 females, with an age range of 22-95 years old. Serum samples were collected for 25(OH)D and BTMs detection. BMD of the lumbar spine, femoral neck, and total hip of the subjects were measured by dual-energy X-ray absorptiometry.  Results  The proportion of 25(OH)D insufficiency and deficiency in the study population was 39.7% (1 236/3 117) and 9.1% (284/3 117), respectively. After grouping by age, the proportion of 25(OH)D deficiency was highest in men and women under 50 years of age, with 11.1% (21/189) and 31.0% (139/449), respectively. After grouping by gender, 25(OH)D levels were negatively associated with special sequence β carboxyterminal peptide of collagen Ⅰ (β-CTX) levels in men and women (male: r=-0.161, P < 0.001; female: r=-0.069, P=0.002). In addition, 25(OH)D levels were positively associated with femoral neck BMD (β=0.001, P=0.019) and total hip BMD (β=0.001, P=0.034) in men.  Conclusion  25(OH)D deficiency and insufficiency are still common in rural areas of Ningbo City, especially among women younger than 50 years old. The results suggest that these people need to pay more attention to their 25(OH)D levels and adjust their lifestyle or use vitamin D supplements early. In addition, 25(OH)D levels were found to be positively associated with BMD and negatively associated with β-CTX levels in this study population.

     

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