Volume 23 Issue 1
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XU Xunhong, XU Maohua, LI Xiaohong. Dynamic changes in metabolic indexes following organophosphorus poisoning and their correlation with prognosis in hospital[J]. Chinese Journal of General Practice, 2025, 23(1): 94-97. doi: 10.16766/j.cnki.issn.1674-4152.003843
Citation: XU Xunhong, XU Maohua, LI Xiaohong. Dynamic changes in metabolic indexes following organophosphorus poisoning and their correlation with prognosis in hospital[J]. Chinese Journal of General Practice, 2025, 23(1): 94-97. doi: 10.16766/j.cnki.issn.1674-4152.003843
shu

Dynamic changes in metabolic indexes following organophosphorus poisoning and their correlation with prognosis in hospital

doi: 10.16766/j.cnki.issn.1674-4152.003843
  • 1.

    Department of Emergency, Chun' an Branch of Zhejiang Provincial People' s Hospital, Hangzhou, Zhejiang 311700, China

Funds:

 2023XY144

  • Received Date: 2024-01-25
    Available Online: 2025-02-13
    Abstract
  •   Objective   Organophosphorus poisoning has an acute onset and progresses rapidly. Without timely treatment, it may lead to coma or even death. Metabolic indexes change dynamically following acute organophosphorus poisoning, which have the potential value to predict the prognosis of organophosphorus poisoning. Therefore, this study explores the correlation between the dynamic changes of metabolic indexes and prognosis of patients.   Methods   From January 2021 to December 2022, 245 patients with organophosphorus poisoning at the Emergency Medicine Department of the Chun' an Branch of Zhejiang Provincial People' s Hospital were selected as the research object. The blood samples were collected within 72 hours post-poisoning, and the dynamic changes of metabolic indexes were analyzed. At the same time, the prognosis of patients with organophosphorus poisoning were collected, and the correlation between the dynamic changes in metabolic indexes and prognosis was analyzed by Cox regression analysis.   Results   The random blood sugar, sodium ion, serum creatinine, and blood urea nitrogen all changed dynamically within 72 hours after poisoning, while the chloride ion level showed no significant variation. Among the 245 patients, 56 (poor prognosis group) died, while 189 (improved prognosis group) recovered. The sodium ion (HR=2.958, P=0.021), serum creatinine (HR=4.759, P < 0.001), blood urea nitrogen (HR=7.101, P < 0.001), old age (HR=1.109, P=0.001), and longer time from poisoning to admission (HR=6.872, P < 0.001) were the risk factors for the death of patients with organophosphate poisoning. High AChE activity was identified as a protective factor for the death of patients with organophosphorus poisoning (HR=0.910, P < 0.05).   Conclusion   The patients' random blood sugar, sodium ion, serum creatinine, and blood urea nitrogen exhibit dynamic changes within 72 hours after poisoning, while chloride ion levels remain stable. Dynamic changes in sodium ion, serum creatinine, and blood urea nitrogen, as well as age, time to admission, and AChE activity, are significantly related to the prognosis of patients with organophosphorus poisoning.

     

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