Volume 23 Issue 1
Jan.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(1): 122-126
HU Xuemei, PAN Baolong, BAI Yingying, YANG Yang. Research progress of exosome-deriveds non-coding RNA in osteosarcoma metastasis[J]. Chinese Journal of General Practice, 2025, 23(1): 122-126. doi: 10.16766/j.cnki.issn.1674-4152.003849
Citation: HU Xuemei, PAN Baolong, BAI Yingying, YANG Yang. Research progress of exosome-deriveds non-coding RNA in osteosarcoma metastasis[J]. Chinese Journal of General Practice, 2025, 23(1): 122-126. doi: 10.16766/j.cnki.issn.1674-4152.003849
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Research progress of exosome-deriveds non-coding RNA in osteosarcoma metastasis

doi: 10.16766/j.cnki.issn.1674-4152.003849

  • Department of Clinical Laboratory, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan 653100, China

Funds:

 81960487

  • Received Date: 2024-05-11
    Available Online: 2025-02-13
    Abstract
  • Osteosarcoma (OS) is a malignant bone tumor primarily affects in children and adolescents, characterized by rapid progression, high malignancy, and easy metastasis. Metastasis of osteosarcoma often occurs in the early stage of the disease, with the lungs being the primary site of spread, contributing significantly to treatment failure and poor prognosis. Exosomes, extracellular vesicles ranging from 40 to 160 nm in diameter, are secreted by a variety of cells and present in numerous body fluids. They play key roles in intercellular communication and maintaining cell structure. Exosomes contain many bioactive substances, such as protein, lipids, mRNA, and ncRNA, which plays a key role in the distant metastasis of osteosarcoma through intercellular signaling. Among the various ncRNAs, miRNA, lncRNA, and circRNA have been widely studied for their roles in regulating osteosarcoma metastasis at multiple molecular levels. The expression levels of exosomal ncRNA in osteosarcoma can either be increased or decreased, influencing tumor progression and metastasis of osteosarcoma by improving cell invasion and migration, inducing epithelial-mesenchymal transition, promoting angiogenesis, and activating related signal pathways. In terms of drug resistance, exosomes can induce drug resistance in sensitive cells by transmitting ncRNA. Due to their unique biological characteristics, exosomes hold great potential as biomarkers for diagnosis, prognosis, and osteosarcoma metastasis. In recent years, exosomal ncRNAs gained considerable attetion in the mechanistic study and clinical application of osteosarcoma. This paper reviews the role of exosomal ncRNA in osteosarcoma metastasis, chemotherapy resistance, and as a potential biomarker, in order to provide insights into the mechanisms, treatment strategies, and prognosis of osteosarcoma metastasis.

     

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