Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis

HAN Kang; JING Wenjiang; WU Yongsheng; LI Yuan; FAN Zhigang

doi:10.16766/j.cnki.issn.1674-4152.003867

Volume 23 Issue 2

Feb. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(2): 203-206

HAN Kang, JING Wenjiang, WU Yongsheng, LI Yuan, FAN Zhigang. Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis[J]. Chinese Journal of General Practice, 2025, 23(2): 203-206. doi: 10.16766/j.cnki.issn.1674-4152.003867

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HAN Kang, JING Wenjiang, WU Yongsheng, LI Yuan, FAN Zhigang. Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis[J]. Chinese Journal of General Practice, 2025, 23(2): 203-206. doi: 10.16766/j.cnki.issn.1674-4152.003867

Citation:

HAN Kang, JING Wenjiang, WU Yongsheng, LI Yuan, FAN Zhigang. Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis[J]. Chinese Journal of General Practice, 2025, 23(2): 203-206. doi: 10.16766/j.cnki.issn.1674-4152.003867

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Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis

doi: 10.16766/j.cnki.issn.1674-4152.003867

1.
Department of Respiratory and Critical Care Medicine, 3201 Hospital, Hanzhong, Shaanxi 723000, China

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2021SF-044

Received Date: 2024-07-21
Available Online: 2025-03-27

Abstract

Abstract

Objective To investigate the expression and clinical significance of LncRNA-DGCR5 in non-small cell lung cancer (NSCLC). Methods A total of 105 NSCLC patients admitted to 3201 Hospital from January 2020 to January 2021 were collected. The expression levels of LncRNA-DGCR5 were detected, and the patients were divided into a low expression group (n = 41) and a high expression group (n = 64). The relationship between the expression level of LncRNADGCR5, the radiotherapy efficacy, and prognosis of patients was analyzed. Results The expression level of LncRNADGCR5 in cancer tissues was significantly lower than that in adjacent tissues (1. 21±0. 45 vs. 4. 02±0. 89, t = 28. 872, P < 0. 05). Compared with the high expression group, the proportion of poorly differentiated tumor and TNM stage Ⅲ to Ⅳ in the low expression group was higher (63. 41% vs. 17. 19%, 56. 10% vs. 32. 81%, χ² = 23. 401, 5. 566, P < 0. 05). In contrast to the high expression group, the objective response rate was lower (46. 34% vs. 87. 50%, χ² = 27. 648, P < 0. 05), and the 3-year disease-free survival (DFS) was shorter (27. 00 months vs. 31. 00 months, log-rank χ² = 10. 120, P < 0. 05) in the low expression group. Additionally, patients with low tumor differentiation, TNM stage Ⅲ to Ⅳ, and lymph node metastasis had lower median DFS (28. 15, 28. 66, 27. 45 months, respectively, χ² = 9. 074, 5. 105, 12. 116, all P < 0. 05). Tumor differentiation, TNM stage, lymph node metastasis, and LncRNA-DGCR5 expression were all significantly associated with median DFS in NSCLC patients (P < 0. 05). Conclusion LncRNA-DGCR5 is expressed at low levels in NSCLC tissues and is closely related to the radiotherapy efficacy and patient prognosis.
- LncRNA-DGCR5,
- Non-small cell lung cancer,
- Radiotherapy efficacy,
- Prognosis

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Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis

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Expression of LncRNA-DGCR5 in non-small cell lung cancer and its correlation with radiotherapy efficacy and prognosis

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