Volume 23 Issue 2
Feb.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(2): 223-226
PAN Fei, XU Tong, ZHANG Jingdan, ZHAO Zheng, LI Yadi, XU Yanan, XU Yahui. To investigate the efficacy of idebenone combined with sertraline in the treatment of elderly patients with post-stroke depression, and its effect on cognitive function and oxidative stress[J]. Chinese Journal of General Practice, 2025, 23(2): 223-226. doi: 10.16766/j.cnki.issn.1674-4152.003872
Citation: PAN Fei, XU Tong, ZHANG Jingdan, ZHAO Zheng, LI Yadi, XU Yanan, XU Yahui. To investigate the efficacy of idebenone combined with sertraline in the treatment of elderly patients with post-stroke depression, and its effect on cognitive function and oxidative stress[J]. Chinese Journal of General Practice, 2025, 23(2): 223-226. doi: 10.16766/j.cnki.issn.1674-4152.003872
shu

To investigate the efficacy of idebenone combined with sertraline in the treatment of elderly patients with post-stroke depression, and its effect on cognitive function and oxidative stress

doi: 10.16766/j.cnki.issn.1674-4152.003872
  • 1.

    Fourth Department of Psychiatry, Second Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453000, China

Funds:

 LHGJ20190481

  • Received Date: 2024-08-11
    Available Online: 2025-03-27
    Abstract
  •   Objective  To investigate the efficacy of idebenone combined with sertraline in elderly patients with post-stroke depression (PSD), and to analyze its effect on cognitive function and oxidative stress.  Methods  A total of 104 cases elderly patients with PSD were Seleeted and divided into a control group and study group, 52 cases in each group, and were treated with sertraline, edbenquinone combined with sertraline for 8 weeks, respectively.The Hamilton depression scale (HAMD) scores of the two groups were observed before treatment, 4 and 8 weeks after treatment.The clinical efficacy, cognitive function[mini-mental state examination (MMSE), Webster's adult memory scale (WMS-RC)], oxidative stress index[superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, glutathione peroxidase (GSH-PX) activity]before and after treatment and safety were evaluated.  Results  After 4 and 8 weeks of treatment, the inter-group effect, time effect, and interaction effect were significant (P < 0.05).The HAMD score of the study group was lower than that of the control group after 4 and 8 weeks of treatment, and the HAMD score of the study group had a more obvious decreasing trend with the extension of time.The total clinical effective rate was 96.15%(50 cases) in the study group and 82.69%(43 cases) in the control group, and the study group was higher than the control group (χ2=4.981, P=0.026).Compared with before treatment, MMSE scores, long-term memory, short-term memory, immediate memory, memory quotient, serum SOD and GSH-PX activities were increased in both groups after treatment, and higher in the study group (P < 0.05).The MDA levels in the 2 groups after treatment were decreased compared with before treatment, especially in the study group (P < 0.05).There was no significant difference in the incidence of adverse reactions between the study group (9.61%, 5 cases) and the control group (5.77%, 3 cases, P>0.05).  Conclusion  The use of idbenquinone combined with sertraline in elderly PSD patients is safe and reliable in alleviating depressive symptoms, improving clinical efficacy, improving cognitive function, and alleviating oxidative stress damage.

     

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