Volume 23 Issue 2
Feb.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(2): 257-260
LI Min, ZHENG Shumin, ZHANG Hongxia, DAI Chengcheng, LIU Chao, YU Peng. The correlation between uterine artery ultrasound parameters, serum PIGF level and the risk of preeclampsia during pregnancy[J]. Chinese Journal of General Practice, 2025, 23(2): 257-260. doi: 10.16766/j.cnki.issn.1674-4152.003880
Citation: LI Min, ZHENG Shumin, ZHANG Hongxia, DAI Chengcheng, LIU Chao, YU Peng. The correlation between uterine artery ultrasound parameters, serum PIGF level and the risk of preeclampsia during pregnancy[J]. Chinese Journal of General Practice, 2025, 23(2): 257-260. doi: 10.16766/j.cnki.issn.1674-4152.003880
shu

The correlation between uterine artery ultrasound parameters, serum PIGF level and the risk of preeclampsia during pregnancy

doi: 10.16766/j.cnki.issn.1674-4152.003880
  • 1.

    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University Dezhou Hospital Shandong University, Dezhou, Shandong 253000, China

Funds:

 2019WS019

  • Received Date: 2024-05-21
    Available Online: 2025-03-27
    Abstract
  •   Objective  To analisis significance of uterine artery ultrasound parameters and serum placental growth factor (PIGF) levels in preeclampsia patients.  Methods  A total of 80 pregnant women with preeclampsia admitted to Dezhou Hospital of Qilu Hospital of Shandong University from January 2022 to December 2023 were included as the observation group and were divided into mild/severe preeclampsia subgroup, and 30 healthy pregnant women during the same period were included as the control group.The ultrasonic parameters of uterine artery[resistance index (RI), pulse index (PI), systolic to diastolic flow velocity ratio (S/D)]and serum PIGF levels were compared; The correlation between uterine artery ultrasound parameters, PIGF, and preeclampsia was analyzed by logistic regression; The receiver operating characteristic curve (ROC) were used to evaluate the value of uterine artery ultrasound parameters and PIGF in the severity of preeclampsia.  Results  RI (0.62±0.12), PI (1.64±0.32) and S/D (0.58±0.18) in the observation group were higher than those in control group (0.56±0.10, 1.30±0.17, 0.46±0.18), but serum PIGF[(33.24±7.36) pg/mL]was lower (P < 0.05);RI, PI, and S/D were risk factors for preeclampsia, and PIGF was a protective factor (P < 0.05).There were 25 mild cases and 55 severe cases in the observation group.RI, PI, and S/D in the severe preeclampsia subgroup were significantly higher, and PIGF was significantly lower (P < 0.05);The area under the curve (AUC) of RI and PI in evaluating the severity of preeclampsia were 0.565 and 0.568(P>0.05), and those of S/D, PIGF, and combined detection were 0.685, 0.648, and 0.774, respectively (P < 0.05).  Conclusion  RI, PI, and S/D in pregnant women with preeclampsia increase, but serum PIGF levels decrease, which is associated with the onset of preeclampsia, and the combined detection can assess the severity of preeclampsia.

     

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