Volume 23 Issue 2
Feb.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(2): 269-272
JIANG Meihong, YUAN Chen. Clinical observation of fiberoptic bronchoscopy bronchoalveolar lavage in the treatment of refractory Mycoplasma pneumonia pneumonia in children[J]. Chinese Journal of General Practice, 2025, 23(2): 269-272. doi: 10.16766/j.cnki.issn.1674-4152.003883
Citation: JIANG Meihong, YUAN Chen. Clinical observation of fiberoptic bronchoscopy bronchoalveolar lavage in the treatment of refractory Mycoplasma pneumonia pneumonia in children[J]. Chinese Journal of General Practice, 2025, 23(2): 269-272. doi: 10.16766/j.cnki.issn.1674-4152.003883
shu

Clinical observation of fiberoptic bronchoscopy bronchoalveolar lavage in the treatment of refractory Mycoplasma pneumonia pneumonia in children

doi: 10.16766/j.cnki.issn.1674-4152.003883
  • 1.

    Department of Pediatrics, Changxing County People ' s Hospital, Huzhou, Zhejiang 313100, China

Funds:

 2021KY348

  • Received Date: 2024-09-10
    Available Online: 2025-03-27
    Abstract
  •   Objective  The treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children is difficult. In order to improve the prognosis of children, this study explores the clinical effect of fiberoptic bronchoscopy bronchoalveolar lavage in the treatment of RMPP in children.  Methods  A total of 90 children with RMPP admitted to Changxing County People ' s Hospital from June 2020 to June 2024 were selected as the research objects. The children were divided into the control group (45 cases) and the observation group (45 cases) by the random number table method. The two groups received the same basic treatment, with the observation group receiving treatment with fiberoptic bronchoscopy and bronchoalveolar lavage. The clinical efficacy, improvement of clinical symptoms, levels of serum inflammatory markers and lung injury markers of RMPP were evaluated, and RMPP related complications within one month after the end of treatment was followed up.  Results  The overall treatment efficacy rate of RMPP in the observation group [97.78% (44/45)] was significantly higher than that in the control group [82.22% (37/45), χ2=4.444, P=0.035]. The duration of clinical symptoms such as fever, cough, and wet rales in the observation group were significantly shorter than those in the control group (P < 0.001). The serum SF and LDH levels in the observation group after treatment were significantly lower than those in the control group. The serum levels of TNF-α, hs-CRP, PCT, and IL-6 in the observation group after treatment were significantly lower than those in the control group (P < 0.001). The overall incidence of RMPP related complications within one month after treatment in the observation group [4.44% (2/45)] was significantly lower than that in the control group [20.00% (9/45), P < 0.05].  Conclusion  Fiberoptic bronchoscopy bronchoalveolar lavage is used to treat RMPP in children, by clearing airway inflammatory secretions, reducing inflammatory reactions and lung damage, promoting rapid improvement of clinical symptoms, and enhancing efficacy.

     

    • FullText(HTML)
  • loading
    • References(18)
  • [1]
    李小象, 郝建华, 侯红丽, 等. 支原体肺炎患儿流行病学特征及难治性的危险因素分析[J]. 中国临床医生杂志, 2023, 51(9): 1111-1114. doi: 10.3969/j.issn.2095-8552.2023.09.032

    LI X X, HAO J H, HOU H L, et al. Epidemiological characteristics and risk factors for refractory mycoplasma pneumoniae pneumonia in children[J]. Chin J Clinician, 2023, 51(9): 1111-1114. doi: 10.3969/j.issn.2095-8552.2023.09.032
    [2]
    AHN J G, CHO H K, LI D H, et al. Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis[J]. BMC Infect Dis, 2021, 21(1): 1003. DOI: 10.1186/s12879-021-06508-7.
    [3]
    吕晓娟, 汤卫红, 沈道江, 等. 布地奈德联合阿奇霉素序贯疗法对儿童肺炎支原体肺炎肺功能及炎症因子的影响[J]. 中华全科医学, 2019, 17(4): 594-596, 677. doi: 10.16766/j.cnki.issn.1674-4152.000744

    LYU X J, TANG W H, SHEN D J, et al. Effects of budesonide combined with azithromycin sequential therapy on pulmonary function, levels of CRP, IL-6 and TNF-α in children with mycoplasma pneumoniae[J]. Chinese Journal of General Practice, 2019, 17(4): 594-596, 677. doi: 10.16766/j.cnki.issn.1674-4152.000744
    [4]
    中华医学会儿科学分会呼吸学组, 编辑委员会中华实用儿科临床杂志. 儿童肺炎支原体肺炎诊治专家共识(2015年版)[J]. 中华实用儿科临床杂志, 2015, 30(17): 1304-1308. doi: 10.3760/cma.j.issn.2095-428X.2015.17.006

    The Respiratory Group of the Chinese Medical Association, Editorial Committee of the Chinese Journal of Practical Pediatric Clinical Medicine. Expert consensus on diagnosis and treatment of mycoplasma pneumoniae pneumonia in children (2015)[J]. Chinese Journal of Applied Clinical Pediatrics, 2015, 30(17): 1304-1308. doi: 10.3760/cma.j.issn.2095-428X.2015.17.006
    [5]
    李洁, 马洋, 尹君平, 等. 肺炎支原体耐药和儿童难治性肺炎支原体肺炎的关系研究[J]. 华北理工大学学报(医学版), 2024, 26(4): 279-282, 290.

    LI J, MA Y, YIN J P, et al. Study on the relationship between Mycoplasma pneumoniae resistance and refractory mycoplasma pneu-moniae pneumonia in children[J]. Journal of HeBei United University (Health Sciences), 2024, 26(4): 279-282, 290.
    [6]
    孙慧, 徐梅先, 李君娥, 等. 肺泡灌洗液社区获得性呼吸窘迫综合征毒素表达与难治性肺炎支原体肺炎发生风险的相关性[J]. 中华实用诊断与治疗杂志, 2023, 37(4): 406-409.

    BAO R Y, XU G C. Progress om mechanism and treatment of refractory mycoplasma pneumoniae pneumoniain children[J]. Journal of Qiqihar University of Medicine, 2023, 37(4): 406-409.
    [7]
    ZHANG H, YANG J J, ZHAO W Q, et al. Clinical features and risk factors of plastic bronchitis caused by refractory Mycoplasma pneumoniae pneumonia in children: a practical nomogram prediction model[J]. Eur J Pediatr, 2023, 182(3): 1239-1249.
    [8]
    李富, 雷国峰, 赵宇欣, 等. 不同剂量甲泼尼龙治疗儿童难治性肺炎支原体肺炎的临床研究[J]. 西南医科大学学报, 2023, 46(6): 513-516, 529. doi: 10.3969/j.issn.2096-3351.2023.06.011

    LI F, LEI G F, ZHAO Y X, et al. Treatment of refractory mycoplasma pneumoniae pneumonia in children with different doses of methylprednisolone[J]. Journal of Luzhou Medical College, 2023, 46(6): 513-516, 529. doi: 10.3969/j.issn.2096-3351.2023.06.011
    [9]
    赵春兰, 赵梅, 王运芬, 等. 儿童难治性肺炎支原体肺炎的危险因素及甲泼尼龙治疗的最佳剂量探讨[J]. 现代生物医学进展, 2022, 22(11): 2181-2185.

    ZHAO C L, ZHAO M, WANG Y F, et al. Risk factors of refractory mycoplasma pneumoniae pneumonia in children and explore the optimal dose of methylprednisolone treatment[J]. Progress in Modern Biomedicine, 2022, 22(11): 2181-2185.
    [10]
    刘雪莲, 李文联. 金振口服液联合甲泼尼龙治疗儿童难治性肺炎支原体肺炎临床疗效及对肺功能的影响[J]. 湖北中医药大学学报, 2022, 24(2): 27-30.

    LIU X L, LI W L. Clinical curative effect of Jinzhen Oral Liquid combined with methylprednisolone on children with refractory mycoplasma pneumoniae pneumonia and its influences on pulmonary function[J]. Journal of Hubei University of Chinese Medicine, 2022, 24(2): 27-30.
    [11]
    ZHOU H, CHEN X J, LI J. Effect of methylprednisolone plus azithromycin on fractional exhaled nitric oxide and peripheral blood eosinophils in children with refractory Mycoplasma pneumoniae pneumonia[J]. J Coll Physicians Surg Pak, 2022, 32(1): 33-36. doi: 10.29271/jcpsp.2022.01.33
    [12]
    王子威, 胡彦宏, 何瑜娜, 等. 纤维支气管镜肺泡灌洗与甲泼尼龙治疗难治性肺炎支原体肺炎的疗效比较[J]. 北京医学, 2021, 43(2): 126-129.

    WANG Z W, HU Y H, HE Y N, et al. Therapeutic effects comparison of bronchoscopic alveolar lavage and methylprednisolone on refractory mycoplaama pneumoniae pneumonia[J]. Beijing Medical Journal, 2021, 43(2): 126-129.
    [13]
    周梅, 訾和平. 肺炎支原体肺炎患儿入院时血清S100钙结合蛋白、骨桥蛋白水平变化及其预后预测效能[J]. 山东医药, 2024, 64(36): 6-10.

    ZHOU M, ZI H P. Changes in levels of serum S100 calcium binding protein and osteopontin in children with mycoplasma pneumoniae pneumonia at admission and their predictive efficacy for prognosis[J]. Shandong Medical Journal, 2024, 64(36): 6-10.
    [14]
    吴振波, 蔡志明, 黄宝瑶, 等. 经支气管镜防污染采样刷检在儿童难治性肺炎病原学诊断中的价值[J]. 中国内镜杂志, 2021, 27(3): 82-88.

    WU Z B, CAI Z M, HUANG B Y, et al. Clinical value of bronchoscope anti-pollution sampling and brushing in the pathogenic diagnosis of refractory pneumonia in children[J]. China Journal of Endoscopy, 2021, 27(3): 82-88.
    [15]
    LU W H, WU X T, XU Y L, et al. Predictive value of bronchoscopy combined with CT score for refractory Mycoplasma pneumoniae pneumonia in children[J]. BMC Pulm Med, 2024, 24(1): 251. DOI: 10.1186/s12890-024-02996-w.
    [16]
    YU M, ZHANG Q, YAN H O. Cytokines and refractory Mycoplasma pneumoniae pneumonia in children: a systematic review[J]. Minerva Pediatr (Torino), 2024, 76(2): 259-267.
    [17]
    冯荣光, 窦蕊, 李占文, 等. 支气管镜结合全身联合用药治疗儿童难治性支原体肺炎的疗效分析[J]. 内蒙古医科大学学报, 2022, 44(2): 151-154, 157.

    FENG R G, DOU R, LI Z W, et al. Analysis of the therapeutic effect of bronchoscopy combined with systemic medication in the treatment of refractory mycoplasma pneumonia in children[J]. Journal of Inner Mongolia Medical University, 2022, 44(2): 151-154, 157.
    [18]
    吴建武, 廖汉杰. 盐酸氨溴索经纤维支气管镜肺泡灌洗治疗儿童难治性肺炎支原体肺炎的疗效及安全性分析[J]. 右江医学, 2022, 50(8): 577-581.

    WU J W, LIAO H J. Analysis on efficacy and safety of ambroxol hydrochloride by fiberoptic bronchoalveolar lavage in the treatment of refractory Mycoplasma pneumoniae pneumonia in children[J]. Youjiang Medical Journal, 2022, 50(8): 577-581.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (12) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return