Volume 23 Issue 2
Feb.  2025
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ZHANG Weijie, Abudureheman·Zebibula, QIAO Bingzhang, Mulati·Rexiati. Research progress of near-infrared fluorescence imaging in the diagnosis and treatment of urinary system diseases[J]. Chinese Journal of General Practice, 2025, 23(2): 286-291. doi: 10.16766/j.cnki.issn.1674-4152.003887
Citation: ZHANG Weijie, Abudureheman·Zebibula, QIAO Bingzhang, Mulati·Rexiati. Research progress of near-infrared fluorescence imaging in the diagnosis and treatment of urinary system diseases[J]. Chinese Journal of General Practice, 2025, 23(2): 286-291. doi: 10.16766/j.cnki.issn.1674-4152.003887
shu

Research progress of near-infrared fluorescence imaging in the diagnosis and treatment of urinary system diseases

doi: 10.16766/j.cnki.issn.1674-4152.003887

  • Department of Urology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China

Funds:

 82260139

 82360353

 2022D01C763

  • Received Date: 2024-01-04
    Available Online: 2025-03-27
    Abstract
  • Traditional examinations for urinary diseases are of great importance in the clinical diagnosis and treatment of patients. However, these methods entail a number of potential risks, including lengthy test times, excessive exposure to X-rays or radioisotopes due to the frequency of tests, and the possibility of an allergic reaction to contrast media. Optical imaging is a radiation-free, high-spatiotemporal-resolution, and high sensitivity real-time imaging technology with a wide range of potential applications. In comparison to visible light, near-infrared light has the capacity to significantly enhance both the penetration depth and fluorescence intensity, while simultaneously providing a high signal-to-noise ratio imaging effect. In addition to providing a clear image of urinary system anatomy, this method can also be employed for the early, non-invasive assessment of renal function. Furthermore, due to their advantageous renal clearance rate and specific binding to tumors, certain probes can be employed to assess intraoperative repair of damaged ureters, direct tumor resection and ascertain the characteristics of incisal margins, and possess the capacity for surgical navigation. As a topic of considerable current interest in the scientific community, near infrared fluorescence imaging has demonstrated considerable potential in the diagnosis and treatment of urinary diseases. The objective of this review is to provide a comprehensive summary of the preparation strategies for relevant fluorescent probes along with their research progress in the field of urinary system structure, function, and tumor imaging. Additionally, it will highlight the limitations associated with NIR fluorescence imaging and offer insights into potential future applications.

     

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