Volume 23 Issue 3
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LI Siman, CHEN Juan, ZHANG Wenjie. Expression of serum asprosin in patients with gestational diabetes mellitus and its correlation with glucose and lipid metabolism[J]. Chinese Journal of General Practice, 2025, 23(3): 362-364. doi: 10.16766/j.cnki.issn.1674-4152.003904
Citation: LI Siman, CHEN Juan, ZHANG Wenjie. Expression of serum asprosin in patients with gestational diabetes mellitus and its correlation with glucose and lipid metabolism[J]. Chinese Journal of General Practice, 2025, 23(3): 362-364. doi: 10.16766/j.cnki.issn.1674-4152.003904
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Expression of serum asprosin in patients with gestational diabetes mellitus and its correlation with glucose and lipid metabolism

doi: 10.16766/j.cnki.issn.1674-4152.003904
  • 1.

    Department of Women's Health Care, Northwest Women and Children's Hospital, Xi'an, Shaanxi 710061, China

Funds:

 2022SF-277

  • Received Date: 2024-04-12
    Available Online: 2025-05-14
    Abstract
  •   Objective  To investigate whether there is abnormal expression of serum asprosin in patients with gestational diabetes mellitus (GDM), and to analyze its relationship with glycolipid metabolism indexes, so as to provide new ideas for the pathogenesis of GDM.  Methods  A total of 86 GDM patients (GDM group) and 50 healthy pregnant women (control group) were selected from Northwest Women and Children's Hospital from April 2020 to April 2021. GDM patients were divided into a high-expression group (n=44) and a low-expression group (n=42). Glucose and lipid metabolism indexes and serum asprosin level were detected, the correlation between serum asprosin and other indexes was analyzed, and the risk factors of GDM were analyzed by multi-factor logistic regression.  Results  The level of serum asprosin in the GDM group [(2.56±0.61) ng/mL] was higher than that in the control group [(1.12±0.43) ng/mL, P < 0.05]. Serum asprosin were positively correlated with triacylglycerol, total cholesterol, fasting blood glucose (FBG), fasting insulin (FINS), and insulin resistance index (HOMA-IR) in GDM patients (r=0.312, 0.327, 0.403, 0.462, 0.518, all P < 0.05). High levels of FBG (OR=3.216, 95% CI: 1.434-7.210), FINS (OR=2.869, 95% CI: 1.395-5.902), HOMA-IR (OR=3.511, 95% CI: 1.456-8.466), serum asprosin (OR=2.659, 95% CI: 1.295-7.003) were risk factors for GDM (P < 0.05).  Conclusion  The high expression of serum asprosin in patients with GDM is closely related to the level of glucose and lipid metabolism.

     

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