Volume 23 Issue 3
Mar.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(3): 392-396
LI Yang*, WANG Kai, SONG Zonggong. Expression and clinical significance of miR-330-3p and AXIN1295aa in gastric cancer[J]. Chinese Journal of General Practice, 2025, 23(3): 392-396. doi: 10.16766/j.cnki.issn.1674-4152.003911
Citation: LI Yang*, WANG Kai, SONG Zonggong. Expression and clinical significance of miR-330-3p and AXIN1295aa in gastric cancer[J]. Chinese Journal of General Practice, 2025, 23(3): 392-396. doi: 10.16766/j.cnki.issn.1674-4152.003911
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Expression and clinical significance of miR-330-3p and AXIN1295aa in gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.003911
  • 1.

    Gastroenterology, the Affiliated Nanyang Second General Hospital, Xinxiang Medical University, Nanyang, Henan 473012, China

Funds:

 LHGJ20210977

  • Received Date: 2024-02-26
    Available Online: 2025-05-14
    Abstract
  •   Objective  miRNA and the Wnt/β-catenin signaling pathway play important roles in the occurrence and development of tumors. This study aims to explore the effects of miRNA-330-3p (miR-330-3p) and axis suppressor protein 1295aa (AXIN1295aa) expression on gastric cancer.  Methods  A total of 130 patients with gastric cancer admitted to Nanyang Second General Hospital from January to October 2020 were selected. The mRNA expression of miR-330-3p and AXIN1295aa in gastric cancer tissues was detected by qRT-PCR. The expression level of AXIN1295aa protein was detected by immunohistochemistry.  Results  The expression levels of miR-330-3p and AXIN1295aa mRNA in gastric cancer tissue were significantly higher (1.79±0.24 and 0.52±0.10) than those in normal gastric mucosal tissue (1.05±0.14 and 0.11±0.03, t=30.382, 40.575, P < 0.05). The positivity rate of AXIN1295aa protein in gastric cancer tissue was 70.77%, significantly higher than that in normal gastric mucosal tissue 37.69% (x2=16.426, P < 0.001). There were statistically significant differences in the expression levels of miR-330-3p and AXIN1295aa among patients with different tumor diameter, differentiation degree, TNM staging, lymph node metastasis, and invasion of the serosal layer (P < 0.05). There was a statistically significant difference in the 3-year survival rate of gastric cancer patients with different levels of miR-330-3p and AXIN1295aa expression (P < 0.01). The combination of miR-330-3p and AXIN1295aa had a high predictive value for 3-year mortality risk in gastric cancer patients (AUC=0.846). There was a positive correlation between miR-330-3p and AXIN1295aa mRNA expression levels in gastric cancer tissue.  Conclusion  The high expression of miR-330-3p and AXIN1295aa in gastric cancer tissues is closely related to postoperative survival of patients, and can be used as a potential prognostic indicator.

     

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