Volume 23 Issue 3
Mar.  2025
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PANG Xiyou*, LIAO Junfeng, XU Chaoyang. Analgesic effect of paraneural injection of Esketamine on patients undergoing modified radical mastectomy for breast cancer[J]. Chinese Journal of General Practice, 2025, 23(3): 410-413. doi: 10.16766/j.cnki.issn.1674-4152.003915
Citation: PANG Xiyou*, LIAO Junfeng, XU Chaoyang. Analgesic effect of paraneural injection of Esketamine on patients undergoing modified radical mastectomy for breast cancer[J]. Chinese Journal of General Practice, 2025, 23(3): 410-413. doi: 10.16766/j.cnki.issn.1674-4152.003915
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Analgesic effect of paraneural injection of Esketamine on patients undergoing modified radical mastectomy for breast cancer

doi: 10.16766/j.cnki.issn.1674-4152.003915
  • 1.

    Department of Anesthesiology, Jinhua Central Hospital, Jinhua, Zhejiang 321000, China

Funds:

 LTGG24H310001

  • Received Date: 2024-11-11
    Available Online: 2025-05-14
    Abstract
  •   Objective  To explore the postoperative analgesic effect of paraneural injection of Esketamine in patients undergoing modified radical mastectomy modified radical mastectomy for breast cancer, and to provide reference for clinical formulation of postoperative analgesia program.  Methods  A total of 115 modified radical mastectomy patients admitted to Jinhua Central Hospital from January 2022 to July 2024 were randomly divided into group A (n=57) and group B (n=58) using a random number table method. Group A did not receive perineural injections, while group B received perineural injections of ketamine and ropivacaine. The postoperative recovery quality [15-item quality of recovery (QoR-15)], inflammatory factor levels [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], postoperative analgesic effect (VAS score), sleep quality [Pittsburgh sleep quality index (PSQI)], and adverse reactions (nausea, vomiting, dizziness, delirium) of two groups were observed.  Results  The QoR-15 score in group B [(107.42±7.46) points] was higher than that in group A [(102.17±6.95) points] 72 hours after surgery (P<0.05). The postoperative levels of IL-6 and TNF-α in both groups showed a decreasing trend, with group B showing a greater decrease (P<0.05). The static and dynamic VAS scores of both groups showed an increasing trend after surgery, but the increase in group B was smaller (P<0.05). The PSQI score of group B at 72 hours after surgery [(7.15 ±1.24) points] was lower than that of group A [(8.23±1.41) points, P<0.05]. The incidence of adverse reactions was 8.62% (5/58) in group B and 12.28% (7/57) in group A, and there was no significant difference between the two groups (χ2=0.408, P=0.523).  Conclusion  Paraneural injection of Esketamine can improve the quality of postoperative recovery, reduce inflammatory reactions, alleviate postoperative pain, and improve sleep quality in modified radical mastectomy patients, which is worthy of application.

     

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