Volume 23 Issue 3
Mar.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(3): 439-442
XIAO Jiali, LUO Jing, JIANG Yuming, CAO Fang, ZHANG Yinying, YANG Rongwei. Effects of serum vitamin D levels on neonatal outcomes in pregnant women with preeclampsia[J]. Chinese Journal of General Practice, 2025, 23(3): 439-442. doi: 10.16766/j.cnki.issn.1674-4152.003922
Citation: XIAO Jiali, LUO Jing, JIANG Yuming, CAO Fang, ZHANG Yinying, YANG Rongwei. Effects of serum vitamin D levels on neonatal outcomes in pregnant women with preeclampsia[J]. Chinese Journal of General Practice, 2025, 23(3): 439-442. doi: 10.16766/j.cnki.issn.1674-4152.003922
shu

Effects of serum vitamin D levels on neonatal outcomes in pregnant women with preeclampsia

doi: 10.16766/j.cnki.issn.1674-4152.003922

  • Neonatal Department, Jiaxing Maternal and Child Health Hospital, Jiaxing, Zhejiang 314000, China

Funds:

 2023KY1218

  • Received Date: 2024-05-17
    Available Online: 2025-05-14
    Abstract
  •   Objective  Pregnant women with preeclampsia (PE) have an increased risk of adverse pregnancy outcomes. This study analyzed the relationship between the severity of serum vitamin D (VD) deficiency and gestational age, newborn birth weight, and neonatal adverse outcomes, and provided new ideas for reducing adverse pregnancy outcomes in women with PE.  Methods  A total of 280 PE patients treated in Jiaxing Maternal and Child Health Hospital from January 2023 to December 2023 were selected as the PE group and 280 normal pregnant women as the control group, and the difference of serum 25 (OH) D level between PE patients and control group was compared. PE patients were divided into severe VD deficiency group, mild VD deficiency group, and normal VD group according to serum 25(OH) D level. The binary logistic regression equation was used to investigate the relationship between serum VD deficiency and adverse pregnancy outcomes.  Results  The serum 25(OH)D level in the PE group [(48.29±12.88)nmol/L] was significantly lower than that in the control group [(57.75±11.92)nmol/L], and the difference was statistically significant (P < 0.05). The incidence of severe PE in the severe VD deficiency group was significantly higher than that in the normal VD group and the mild VD deficiency group (P < 0.05), but there was no statistical significance between the normal VD group and the mild VD deficiency group (P>0.05). Gestational age, neonatal birth weight, and Apgar score in severe VD deficiency group were lower than those in normal VD group and mild VD deficiency group, and the incidence of neonatal asphyxia was higher than that in normal VD group and mild VD deficiency group, with statistical significance (P < 0.05), while there was no statistical significance between normal VD group and mild VD deficiency group (P>0.05). There was no significant difference in perinatal mortality among the three groups (P>0.05). Multivariate logistic regression results showed that age >35 years old, BMI>25, severe PE, and VD deficiency were independent risk factors for neonatal adverse outcomes.  Conclusion  Serious deficiency of serum VD increases the risk of adverse neonatal outcomes in PE patients.

     

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