Volume 23 Issue 3
Mar.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(3): 477-480
ZHANG Xiaowei, WANG Guihong. The influence of non-genetic factors on gout[J]. Chinese Journal of General Practice, 2025, 23(3): 477-480. doi: 10.16766/j.cnki.issn.1674-4152.003931
Citation: ZHANG Xiaowei, WANG Guihong. The influence of non-genetic factors on gout[J]. Chinese Journal of General Practice, 2025, 23(3): 477-480. doi: 10.16766/j.cnki.issn.1674-4152.003931
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The influence of non-genetic factors on gout

doi: 10.16766/j.cnki.issn.1674-4152.003931
  • 1.

    The Fifth School of Clinical Medicine of Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 2022AH040324

  • Received Date: 2024-01-24
    Available Online: 2025-05-14
    Abstract
  • The accumulation of urate in the blood and the precipitation formed when the concentration of uric acid in the extracellular fluid is saturated contribute to the deposition of uric acid in the synovium, bursa, cartilage, and other joint tissues, which results in abnormally high levels of uric acid, deriving from a recurring inflammatory disease that can be characterized by recurrent episodes, which is known as gout. Gout may develop as a result of increased purine biosynthesis, leading to excessive production of uric acid, or because of inadequate excretion of uric acid. Uric acid is an intermediate product of purine metabolism that is excreted through the kidneys and feces. When uric acid is either over-produced or under-excreted, the increase in uric acid concentration causes hyperuricemia. In the absence of symptoms such as acute arthritis, hyperuricemia cannot be called gout. It can only be defined as gout when symptoms are present. Gout often coexists with hyperuricemia and is often comorbid with a variety of chronic diseases such as hyperlipidemia, diabetes mellitus, hypertensive disorders, obesity, and coronary artery disease. According to the results of some regional epidemiological surveys, the prevalence of gout in China is estimated to be between 1.0% and 3.0%; the prevalence of hyperuricemia is between 5.5% and 19.3%, and continues to rise. And the impact of gout on the social labor force should not be underestimated, so it is necessary to study the impact of related factors on gout to reduce the incidence and disability rate. In addition to genetic factors, non-genetic factors also play a very important role, so the main focus of this study is to explore the non-genetic factors that may be associated with gout, which include age, gender, diet, alcohol consumption, smoking, medications, comorbidities, seasonality, air pollution, etc. The study will also consider the combined effects of different factors on the onset or exacerbation of gout and provide feasible recommendations for the management of high-risk factors for gout.

     

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