Volume 23 Issue 4
Apr.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(4): 566-569
ZHU Dongmei, GE Dongtao, HAN Ruodong, YANG Miao. Comparison and prognosis of direct thrombectomy and bridging therapy for acute anterior circulation large vessel occlusive stroke[J]. Chinese Journal of General Practice, 2025, 23(4): 566-569. doi: 10.16766/j.cnki.issn.1674-4152.003951
Citation: ZHU Dongmei, GE Dongtao, HAN Ruodong, YANG Miao. Comparison and prognosis of direct thrombectomy and bridging therapy for acute anterior circulation large vessel occlusive stroke[J]. Chinese Journal of General Practice, 2025, 23(4): 566-569. doi: 10.16766/j.cnki.issn.1674-4152.003951
shu

Comparison and prognosis of direct thrombectomy and bridging therapy for acute anterior circulation large vessel occlusive stroke

doi: 10.16766/j.cnki.issn.1674-4152.003951
  • 1.

    Graduate School of Bengbu Medical University, Bengbu, Anhui 233000, China

Funds:

 Byycx23150

 2022A H050688

  • Received Date: 2024-06-24
    Available Online: 2025-06-30
    Abstract
  •   Objective  To compare the efficacy of direct mechanical thrombectomy (dMT) with bridging therapy (BT) in patients with acute ischaemic stroke with anterior circulation large vessel occlusion (AIS-LVO) and to identify factors influencing their prognosis.  Methods  The present study examined the efficacy of dMT and BT in AIS-LVO patients treated at Bozhou Hospital Affiliated to Anhui Medical University, from January 2020 to July 2023. Patients were stratified into two distinct groups, namely the BT group and the dMT group, based on the respective treatment modalities received. A comprehensive set of clinical data was collected, and a comparative analysis of the efficacy of these two treatment modalities was conducted. The factors influencing the prognosis of AIS-LVO were analyzed by univariate and multivariate logistic regression.  Results  A number of significant differences were identified between the two groups in terms of the time of onset, pre-onset modified Rankin scale score, door-to-puncture time, admission National Institute of Health stroke scale (NIHSS) score, proportion of patients with hypertension, moderate-to-severe disability rate and mortality (P < 0.05). Following the implementation of propensity score matching, no statistically significant differences were observed between the two groups with respect to the 90-day good functional outcome rate, symptomatic intracranial hemorrhage rate, or mortality rate (P>0.05). However, the BT group demonstrated a higher rate of moderate to severe disability in comparison to the dMT group. Multivariate logistic regression analysis revealed that age was 60-80 years old (OR=3.421, 95% CI: 1.809-6.471, P < 0.001), high NIHSS scores upon admission (OR=1.069, 95% CI: 1.017-1.124, P=0.009), and history of diabetes (OR=3.252, 95% CI: 1.531-6.908, P=0.002) were independent risk factors for poor prognosis in AIS-LVO patients.  Conclusion  The present study has demonstrated that bridging therapy and direct mechanical thrombectomy demonstrate comparable clinical efficacy and safety in AIS-LVO patients. Furthermore, it has been demonstrated that elevated NIHSS scores upon admission, advanced age and the presence of concomitant diabetes are independent risk factors for poor unfavourable in AIS-LVO.

     

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