The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients

LI Yi; NI Weibo; CHI Yi; SHANG Huanxia; GUO Lijuan

doi:10.16766/j.cnki.issn.1674-4152.003957

Volume 23 Issue 4

Apr. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(4): 588-591

LI Yi, NI Weibo, CHI Yi, SHANG Huanxia, GUO Lijuan. The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients[J]. Chinese Journal of General Practice, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957

Citation:

LI Yi, NI Weibo, CHI Yi, SHANG Huanxia, GUO Lijuan. The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients[J]. Chinese Journal of General Practice, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957

Citation:

LI Yi, NI Weibo, CHI Yi, SHANG Huanxia, GUO Lijuan. The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients[J]. Chinese Journal of General Practice, 2025, 23(4): 588-591. doi: 10.16766/j.cnki.issn.1674-4152.003957

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The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients

doi: 10.16766/j.cnki.issn.1674-4152.003957

LI Yi¹
, NI Weibo²
, CHI Yi²
, SHANG Huanxia³
, GUO Lijuan^{2
,
,}

1.
Department of General Practice, Hebei Chest Hospital (Hebei Lung Cancer Prevention and Treatment Research Center), Shijiazhuang, Hebei 050000, China

Funds:

20242171

Received Date: 2024-05-11
Available Online: 2025-06-30

Abstract

Abstract

Objective To explore the clinical value of nuclear factor kappa-B (NF-κB), interleukin-6 (IL-6), IL-10, interferon-α (IFN-α) and T cell subset count in peripheral blood in predicting the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in order to provide reference for the clinical treatment of the disease. Methods A total of 204 AECOPD patients admitted to Hebei Chest Hospital from June 2023 to March 2024 were studied and separated into poor prognosis group and good prognosis group by the 6-month prognosis. The levels of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood were compared between the two groups, and the prognostic value of the above indexes was analyzed. Results The levels of NF-κB, IL-6, IL-10, IFN-α and CD8⁺ in peripheral blood in the poor prognosis group were higher than those in the good prognosis group (P < 0.05), while CD3⁺, CD4⁺, CD4⁺/CD8⁺ were lower (P < 0.05). Logistic regression analysis showed that NF-κB, IL-6, IL-10, IFN-α, CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in peripheral blood were all related factors affecting the prognosis of AECOPD patients (P < 0.05). Receiver operating characteristic curve analysis results showed that the areas under the curve of peripheral blood NF-κB, IL-6, IL-10, IFN-α, CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ in the prediction of the prognosis of AECOPD patients were 0.804, 0.806, 0.858, 0.842, 0.626, 0.702, 0.724, 0.854, respectively. Conclusion NF-κB, IL-6, IL-10, IFN-α and T cell subset count levels in peripheral blood are closely related to the prognosis of of AECOPD patients, and can be used as an important indicator to predict the prognosis of AECOPD patients.
- Chronic obstructive pulmonary disease,
- Nuclear factor κB,
- Interleukin,
- Interferon-α,
- T cell subsets,
- Prognosis

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References(21)

References

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The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients

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The clinical value of NF-κB, IL-6, IL-10, IFN-α and T cell subsets in peripheral blood in predicting the prognosis of AECOPD patients

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