Volume 23 Issue 4
Apr.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(4): 592-595
XIE Licheng, HUANG Haiyan, FAN Libin, WEI Liliang, HONG Jin. The influence of wet compress of Yanghe Decoction on wound healing in ulcerative-stage lower limb varicose veins under wet healing theory[J]. Chinese Journal of General Practice, 2025, 23(4): 592-595. doi: 10.16766/j.cnki.issn.1674-4152.003958
Citation: XIE Licheng, HUANG Haiyan, FAN Libin, WEI Liliang, HONG Jin. The influence of wet compress of Yanghe Decoction on wound healing in ulcerative-stage lower limb varicose veins under wet healing theory[J]. Chinese Journal of General Practice, 2025, 23(4): 592-595. doi: 10.16766/j.cnki.issn.1674-4152.003958
shu

The influence of wet compress of Yanghe Decoction on wound healing in ulcerative-stage lower limb varicose veins under wet healing theory

doi: 10.16766/j.cnki.issn.1674-4152.003958

  • Department of Vascular Hernia Surgery, Affiliated Hospital of Shaoxing University of Arts and Sciences, Shaoxing, Zhejiang 312000, China

Funds:

 2024ZL1147

  • Received Date: 2024-10-31
    Available Online: 2025-06-30
    Abstract
  •   Objective  This study aims to evaluate the application of Yanghe Decoction wet dressing based on wet healing theory, promoting wound healing in postoperative patients with lower extremity varicose veins at the ulcer stage.  Methods  A total of 96 patients with ulcerated lower extremity varicose veins, admitted to the Affiliated Hospital of Shaoxing University from September 2022 to August 2024, were selected and divided into an observation group and a baseline group based on a random number table method, with 48 patients in each group. The baseline group received postoperative treatment, while the observation group received Yanghe Decoction wet dressing based on the wet healing theory in addition to the baseline treatment. The treatment efficacy, traditional Chinese medicine (TCM) syndrome scores, ulcer area, postoperative wound healing time, and complication rates were evaluated in both groups. Vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α), and transforming growth factor-β1 (TGF-β1) were also measured.  Results  The observation group demonstrated significantly better therapeutic efficacy compared to the baseline group (P < 0.05). After treatment, the scores for the main symptoms of TCM syndromes and the total score in the observation group were lower than those in the baseline group (P < 0.05). The ulcer area and ulcer depth in the observation group after treatment were smaller than those in the baseline group (P < 0.05). The wound healing time in the observation group [(28.33±4.08) days] was shorter than that in the baseline group [(30.25±4.14) days, t=2.289, P < 0.05]. After treatment, the levels of VEGF and TGF-β1 in the observation group were higher than those in the baseline group, while the level of HIF-1αwas lower (P < 0.05). The incidence of complications in the observation group was 6.25% (3/48), which was lower than in the baseline group (20.83%, 10/48, χ2=4.360, P=0.037).  Conclusion  Under the theory of wet healing, the application of Yanghe Decoction wet compress can effectively improve treatment effect, reduce symptoms of patients, promote postoperative wound healing, regulates the levels of VEGF, TGF-β1, and HIF-1α, and reduce complications in patients with ulcer-stage lower extremity varicose veins.

     

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