Volume 23 Issue 4
Apr.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(4): 627-630
WANG Lingyan, LI Yun, MO Yun, CHEN Yaning, LU Jiali, YANG Weiwei, CHEN Yan. Relationship and predictive value of GA/HbA1c levels in late pregnancy and early neonatal hypoglycemia in pregnant women with gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(4): 627-630. doi: 10.16766/j.cnki.issn.1674-4152.003966
Citation: WANG Lingyan, LI Yun, MO Yun, CHEN Yaning, LU Jiali, YANG Weiwei, CHEN Yan. Relationship and predictive value of GA/HbA1c levels in late pregnancy and early neonatal hypoglycemia in pregnant women with gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2025, 23(4): 627-630. doi: 10.16766/j.cnki.issn.1674-4152.003966
shu

Relationship and predictive value of GA/HbA1c levels in late pregnancy and early neonatal hypoglycemia in pregnant women with gestational diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.003966

  • Department of Obstetrics, Huzhou Maternal and Child Health Care Hospital, Huzhou, Zhejiang 313000, China

Funds:

 LGF20H40001

 2022GYB60

  • Received Date: 2024-10-20
    Available Online: 2025-06-30
    Abstract
  •   Objective  This study endeavors to investigate the correlation between the ratio of glycated albumin to glycated hemoglobin (GA/HbA1c) in the third trimester of gestational diabetes mellitus (GDM) pregnancies and the occurrence of early neonatal hypoglycemia, and to investigate the value of this ratio in predicting the risk of neonatal hypoglycemia. This could offer a theoretical foundation for the early clinical identification of high-risk newborns and contribute to reducing complications associated with hypoglycemia.  Methods  A total of 190 pregnant women with GDM were selected from Huzhou Maternity & Child Care Hospital from January 2022 to October 2024. GA and HbA1c levels were detected in the third trimester, and the GA/HbA1c ratio was calculated. The patients with early neonatal hypoglycemia were included in the observation group (n=41), while the remaining patients were included in the control group (n=149). A logistic regression model and forest plot analysis were used to examine the relationship between GA/HbA1c in late pregnancy and early neonatal hypoglycemia. The receiver operating characteristic (ROC) curve was used to assess its predictive value.  Results  The blood glucose level at 30 min, 12 h, and 24 h in the observation group were lower than those in the control group, respectively (P < 0.05). The GA and GA/HbA1c ratio in the observation group were higher than those in the control group (P < 0.05). Without adjustment for confounding factors, each unit increase in GA and GA/HbA1c was associated with a 0.592-fold and 1.087-fold increase in the risk of early neonatal hypoglycemia, respectively. After adjusting for gestational weeks and birth weight of newborns, each unit increase in GA and GA/HbA1c was associated with a 0.641-fold and 0.912-fold, respectively. The AUC values of GA and GA/HbA1c in predicting early neonatal hypoglycemia in the third trimester of GDM were 0.739 and 0.855, respectively. The AUC values for GA/HbA1c in predicting early neonatal hypoglycemia were greater than those for GA alone (Z=2.017, P=0.044).  Conclusion  The increase of GA/HbA1c level in women with GDM in the third trimester is a risk factor for early neonatal hypoglycemia. The GA/HbA1c ratio in the third trimester is expected to be a potential indicator for predicting early neonatal hypoglycemia.

     

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    • References(20)
  • [1]
    SILVANI J, SCHMIDT M I, ZAJDENVERG L, et al. Impact of binge eating during pregnancy on gestational weight gain and postpartum weight retention among women with gestational diabetes mellitus: LINDA-Brasil[J]. Int J Eat Disord, 2020, 53(11): 1818-1825. doi: 10.1002/eat.23361
    [2]
    李林, 张小兰, 黄翠丽. 妊娠期糖尿病患者血清Lp-PLA2、PAPP-A及C肽对新生儿低血糖的预测价值[J]. 中华内分泌外科杂志, 2022, 16(5): 633-636. doi: 10.3760/cma.j.cn.115807-20220517-00124

    LI L, ZHANG X L, HUANG C L. Predictive value of serum Lp-PLA2, PAPP-A combined with C-peptide in patients with gestational diabetes mellitus in predicting neonatal hypoglycemia[J]. Chinese Journal of Endocrine Surgery, 2022, 16(5): 633-636. doi: 10.3760/cma.j.cn.115807-20220517-00124
    [3]
    DE ROSE D U, PERRI A, MAGGIO L, et al. Neonatal hypoglycemia and neurodevelopmental outcomes: yesterday, today, tomorrow[J]. Eur J Pediatr, 2024, 183(3): 1113-1119. doi: 10.1007/s00431-023-05405-2
    [4]
    曾晓琴, 李想, 甘文莉, 等. 妊娠期糖尿病产妇新生儿早期发生低血糖风险预测模型构建与验证[J]. 中国计划生育和妇产科, 2023, 15(8): 79-83.

    ZENG X Q, LI X, GAN W L, et al. Construction and validation of a prediction model for the risk of hypoglycemia in the early stage of newborns of pregnant women with gestational diabetes mellitus[J]. Chinese Journal Of Family Planning & Gynecotokology, 2023, 15(8): 79-83.
    [5]
    陈黎慧, 徐超英, 吴婷婷, 等. 妊娠期糖尿病母亲所娩新生儿低血糖的危险因素分析及风险模型构建[J]. 蚌埠医学院学报, 2023, 48(10): 1441-1444, 1450.

    CHEN L H, XU C Y, WU T T, et al. Analysis on the risk factors and risk model construction of neonatal hypoglycemia delivered by pregnants with gestational diabetes mellitus[J]. Journal of Bengbu Medical College, 2023, 48(10): 1441-1444, 1450.
    [6]
    范翠翠, 陈弘, 李晓牧. 2型糖尿病患者糖化白蛋白/糖化血红蛋白比值与动态血糖参数的相关性分析[J]. 中国临床医学, 2023, 30(3): 509-514.

    FAN C C, CHEN H, LI X M. Correlations between GA/HbA1c ratio and parameters of continuous glucose monitoring in patients with type 2 diabetes mellitus[J]. Chinese Journal of Clinical Medicine, 2023, 30(3): 509-514.
    [7]
    佀思聪, 杨伟, 王洁妤, 等. 老年2型糖尿病患者认知功能与糖化白蛋白及糖化血红蛋白比值的相关性[J]. 国际老年医学杂志, 2023, 44(3): 271-274.

    SI S C, YANG W, WANG J Y, et al. Correlation between cognitive function and ratio of glycated albumin to glycated hemoglobin in older patients with type 2 diabetes mellitus[J]. International Journal of Geriatrics, 2023, 44(3): 271-274.
    [8]
    赵维丽, 徐运强, 郑盼盼, 等. 2型糖尿病患者脂联素、GA/HbA1c比值与周围神经病变的相关性研究[J]. 河北医药, 2022, 44(20): 3131-3134.

    ZHAO W L, XU Y Q, ZHENG P P, et al. Correlation between adiponectin, GA/HbA1c ratio and peripheral neuropathy in patients with type 2 diabetes mellitus[J]. Hebei Medical Journal, 2022, 44(20): 3131-3134.
    [9]
    曹泽毅. 中华妇产科学[M]. 北京: 人民卫生出版社, 2014: 152-157.

    CAO Z Y. Chinese gynecology and obstetrics[M]. Beijing: People' s Medical Publishing House, 2014: 152-157.
    [10]
    胡亚美, 江载芳, 申昆玲, 等. 诸福棠实用儿科学[M]. 8版. 北京: 人民卫生出版社, 2015: 87-89.

    HU Y M, JIANG Z F, SHEN K L, et al. Zhufutang practical pediatrics[M]. 8 edition. Beijing: People' s Medical Publishing House, 2015: 87-89.
    [11]
    李晓芬, 徐萌艳, 徐捷, 等. 母婴皮肤接触时长对妊娠糖尿病产妇新生儿血糖及母乳喂养的影响[J]. 中华全科医学, 2024, 22(6): 1005-1007, 1080. doi: 10.16766/j.cnki.issn.1674-4152.003554

    LI X F, XU M Y, XU J, et al. Effect of mother-infant skin contact duration on blood glucose and breast feeding of newborns of diabetic mother[J]. Chinese Journal of General Practice, 2024, 22(6): 1005-1007, 1080. doi: 10.16766/j.cnki.issn.1674-4152.003554
    [12]
    纪龙花, 韩毓, 许文丽. 分娩前HbA1c水平对GDM孕妇娩出新生儿低血糖风险及出生体重的影响[J]. 中国妇产科临床杂志, 2023, 24(5): 534-535.

    JI L H, HAN Y, XU W L. Effect of pre-delivery HbA1c level on the risk of neonatal hypoglycemia and birth weight in women with GDM[J]. Chinese Journal of Clinical Obstetrics and Gynecology, 2023, 24(05): 534-535.
    [13]
    林玉婷, 杨婷, 李晓勤, 等. 妊娠期糖尿病患者血清果糖胺水平对新生儿低血糖发生的影响[J]. 中国计划生育和妇产科, 2022, 14(2): 80-84.

    LIN Y T, YANG T, LI X Q, et al. Effect of serum fructosamine level on neonatal hypoglycemia in patients with gestational diabetes mellitus[J]. Chinese Journal of Family Planning & Gynecotokology, 2022, 14(2): 80-84.
    [14]
    徐珊珊, 赵晓红, 韩宇洲, 等. 妊娠期糖尿病孕妇分娩新生儿血糖水平变化情况及其低血糖的影响因素分析[J]. 华南预防医学, 2023, 49(4): 440-443, 448.

    XU S S, ZHAO X H, HAN Y Z, et al. Changes in blood glucose and influencing factors of hypoglycemia in neonates born to pregnant women with gestational diabetes mellitus[J]. South China Journal of Preventive Medicine, 2023, 49(4): 440-443, 448.
    [15]
    SIRICHAROENTHAI P, PHUPONG V. Diagnostic accuracy of HbA1c in detecting gestational diabetes mellitus[J]. J Matern Fetal Neonatal Med, 2020, 33(20): 3497-3500.
    [16]
    XIONG W, ZENG ZH, XU Y, et al. Circulating glycated albumin levels and gestational diabetes mellitus[J]. World J Diabetes, 2024, 15(8): 1802-1810.
    [17]
    顾招娣, 任金莲, 郭余娜. 血清糖化白蛋白在妊娠期糖尿病孕妇血糖监测中的应用价值[J]. 中国妇幼保健, 2021, 36(15): 3453-3455.

    GU Z D, REN J L, GUO Y N. Application value of serum glycated albumin in blood glucose monitoring in pregnant women with gestational diabetes mellitus[J]. Maternal & Child Health Care of China, 2021, 36(15): 3453-3455.
    [18]
    SUGAWARA D, SATO H, MAKITA E, et al. Clinical usefulness of glycated albumin and glycated albumin-to-glycated hemoglobin ratio of gestational diabetes mellitus in late pregnancy for predicting infant complications[J]. Pediatr Neonatol, 2022, 63(3): 239-246.
    [19]
    宋夏子. 新生儿低血糖的影响因素及预后状况分析[J]. 中国妇幼保健, 2023, 38(5): 885-888.

    SONG X Z. Analysis of influencing factors and prognosis of neonatal hypoglycemia[J]. Maternal & Child Health Care of China, 2023, 38(5): 885-888.
    [20]
    SI S C, YANG W, LUO H Y, et al. Cognitive decline in elderly patients with type 2 diabetes is associated with glycated albumin, ratio of Glycated Albumin to glycated hemoglobin, and concentrations of inflammatory and oxidative stress markers[J]. Heliyon, 2023, 9(12): e22956-e22963. DOI: 10.1016/j.heliyon.2023.e22956.
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