Volume 23 Issue 4
Apr.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(4): 665-668
WANG Yang, LI Yaoyao, LI Changchang, CHEN Xinchun, LIN Xiaoqiong. Effect of umbilical patch of traditional Chinese medicine on atopic dermatitis in children and its influence on skin barrier function[J]. Chinese Journal of General Practice, 2025, 23(4): 665-668. doi: 10.16766/j.cnki.issn.1674-4152.003975
Citation: WANG Yang, LI Yaoyao, LI Changchang, CHEN Xinchun, LIN Xiaoqiong. Effect of umbilical patch of traditional Chinese medicine on atopic dermatitis in children and its influence on skin barrier function[J]. Chinese Journal of General Practice, 2025, 23(4): 665-668. doi: 10.16766/j.cnki.issn.1674-4152.003975
shu

Effect of umbilical patch of traditional Chinese medicine on atopic dermatitis in children and its influence on skin barrier function

doi: 10.16766/j.cnki.issn.1674-4152.003975

  • Department of Dermatology, Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou, Zhejiang 325001, China

Funds:

 2021ZB277

 Y2020895

  • Received Date: 2024-10-10
    Available Online: 2025-06-30
    Abstract
  •   Objective  Atopic dermatitis (AD) currently lacks specific therapeutic means, and the effect of conventional treatment is limited. This study was to investigate the effect of umbilical patch on children with AD and its effect on skin barrier function.  Methods  A total of 89 children with AD admitted to the dermatology department of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from October 2021 to September 2023 were randomly divided into treatment group and control group, 45 cases and 44 cases, respectively. The control group was given conventional treatment with pimeclimus cream and emollient, and the treatment group was given traditional Chinese medicine (TCM) umbilical patch on the basis of conventional treatment. After 4 weeks of treatment, the therapeutic effect was evaluated by SCORing atopic dermatitis (SCORAD) and symptom score reduction index (SSRI). The changes in laboratory indexes serum immunoglobulin E (IgE), peripheral blood eosinophil count (EOS), skin barrier function [cuticle water content, sebum content, and transcutaneous water loss (TEWL)] were compared.  Results  After treatment, the SCORAD score of both groups decreased compared with that before treatment (P < 0.05), and the treatment group [(11.27±2.64) points vs. (14.01±3.45) points] was lower than that of the control group. SSRI [(53.92±12.79) % vs. (41.23±10.25) %] and total effective rate [95.56% (43/45) vs. 79.55% (35/44)] were higher than those of the control group, the difference was statistically significant (P < 0.05). After treatment, serum IgE, peripheral blood EOS, and TEWL in both groups were decreased compared with that before treatment, and the corneum water content and sebum content in the skin lesions were increased compared with that before treatment (P < 0.05). Serum IgE, peripheral blood EOS, and TEWL in the skin lesions were lower than those in the control group, while the corneum water content and sebum content in the skin lesions were higher than those in the control group. The difference was statistically significant (P < 0.05).  Conclusion  TCM umbilical patch can effectively relieve the symptoms of AD, reduce the level of serum IgE and peripheral blood EOS, improve the skin barrier function, and enhance the clinical effect.

     

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