Volume 23 Issue 6
Jun.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(6): 919-922
WANG Jing, GAN Zhihui, WANG Yidan, WANG Juan. Association of peripheral blood IL-18 levels with the severity of postherpetic neuralgia in herpes zoster patients and its early predictive value[J]. Chinese Journal of General Practice, 2025, 23(6): 919-922. doi: 10.16766/j.cnki.issn.1674-4152.004032
Citation: WANG Jing, GAN Zhihui, WANG Yidan, WANG Juan. Association of peripheral blood IL-18 levels with the severity of postherpetic neuralgia in herpes zoster patients and its early predictive value[J]. Chinese Journal of General Practice, 2025, 23(6): 919-922. doi: 10.16766/j.cnki.issn.1674-4152.004032
shu

Association of peripheral blood IL-18 levels with the severity of postherpetic neuralgia in herpes zoster patients and its early predictive value

doi: 10.16766/j.cnki.issn.1674-4152.004032
  • 1.

    Graduate School of Bengbu Medical University, Bengbu, Anhui 233030, China

Funds:

 2024AH052041

  • Received Date: 2024-12-09
    Available Online: 2025-09-04
    Abstract
  •   Objective  To explore the correlation between the expression level of interleukin-18 (IL-18) in the peripheral blood of herpes zoster patients and the severity of postherpetic neuralgia (PHN) and to evaluate its early warning value for PHN.  Methods  A total of 403 herpes zoster patients who visited the Department of Dermatology at Anhui Provincial Hospital from September 2023 to August 2024 were selected as the observation group, and 226 physical examination subjects during the same period were selected as the control group. The patients were followed up for 3 months to evaluate the occurrence and severity of PHN. According to the presence or absence of PHN, the patients were divided into PHN group (n=157) and non-PHN group (n=246), and the difference in peripheral blood IL-18 levels between the two groups was compared. Univariate and multivariate logistic regression analysis were used to screen the risk factors of PHN. Spearman rank correlation analysis was used to explore the correlation between the severity of PHN and IL-18. ROC curve was used to evaluate the predictive value of IL-18 for PHN.  Results  The peripheral blood IL-18 level in the herpes zoster group was significantly higher than that in the healthy control group (P < 0.05). As the severity of PHN increased, IL-18 levels were significantly elevated compared to the non-PHN group (P < 0.001). Multivariate logistic regression analysis showed that high IL-18 level, female, old age, diabetes, cardiovascular disease, and high VAS score were independent risk factors for PHN. Use of analgesics within 14 days was a protective factor against PHN. Spearman ' s analysis showed a positive correlation between PHN severity and IL-18 levels (r=0.661, P < 0.001). The ROC curve showed that the AUC for IL-18 in predicting PHN was 0.857, with a sensitivity of 83.9%, specificity of 76.8%, and an optimal cutoff value of 1 233.6 pg/mL.  Conclusion  Peripheral blood IL-18 levels during the acute phase of herpes zoster are closely associated with the severity of PHN. IL-18 is one of the risk factors for PHN and has good early warning value for PHN.

     

    • FullText(HTML)
  • loading
    • References(24)
  • [1]
    YANG F, YU S Y, FAN B F, et al. The epidemiology of herpes zoster and postherpetic neuralgia in China: results from a cross-sectional study[J]. Pain Ther, 2019, 8(2): 249-259. doi: 10.1007/s40122-019-0127-z
    [2]
    中华医学会皮肤性病学分会, 中国康复医学会皮肤病康复专业委员会, 中国中西医结合学会皮肤性病学分会, 等. 老年带状疱疹诊疗专家共识[J]. 中华皮肤科杂志, 2023, 56(2): 97-104.

    Chinese Society of Dermatology and Venereology, Committee of Dermatology Rehabilitation of Chinese Rehabilitation Medical Association, Committee of Dermatology and Venereology of Chinese Association of Integrated Traditional Chinese and Western Medicine, et al. Expert consensus on diagnosis and treatment of herpes zoster in the elderly[J]. Chinese Journal of Dermatology, 2023, 56(2): 97-104.
    [3]
    张玉林, 方启帆, 赵永明, 等. 老年带状疱疹急性期METTL3及Gal-3表达水平对带状疱疹后遗神经痛的预测价值[J]. 实用老年医学, 2024, 38(4): 348-352.

    ZHANG Y L, FANG Q F, ZHAO Y M, et al. Predictive value of METTL3 and Gal-3 expression levels during the acute phase of herpes zoster in elderly patients for postherpetic neuralgia[J]. Practical Geriatrics, 2024, 38(4): 348-352.
    [4]
    景海荣, 吕岩. 带状疱疹后神经痛的预防与治疗策略[J]. 中华疼痛学杂志, 2024, 20(2): 161-163.

    JING H R, LYU Y. Strategies for prevention and treatment of postherpetic neuralgia[J]. Chinese Journal of Pain Medicine, 2024, 20(2): 161-163.
    [5]
    陆磊磊, 耿祝生. CT引导下脉冲射频联合神经阻滞治疗头面部带状疱疹后神经痛的临床效果[J]. 中华全科医学, 2024, 22(10): 1696-1699. doi: 10.16766/j.cnki.issn.1674-4152.003714

    LU L L, GENG Z S. Clinical efficacy of CT-guided pulsed radiofrequency combined with nerve block in the treatment of postherpetic neuralgia of head and face[J]. Chinese Journal of General Practice, 2024, 22(10): 1696-1699. doi: 10.16766/j.cnki.issn.1674-4152.003714
    [6]
    IHIM S A, ABUBAKAR S D, ZIAN Z, et al. Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: biological role in induction, regulation, and treatment[J]. Front Immunol, 2022, 13: 919973. DOI: 10.3389/fimmu.2022.919973.
    [7]
    孙蔚, 王慧丽, 岳媛媛, 等. 血清炎症因子白细胞介素-18、高敏C反应蛋白、肿瘤坏死因子-α与2型糖尿病患者颈动脉粥样硬化的关系[J]. 临床内科杂志, 2023, 40(4): 265-267.

    SUN W, WANG H L, YUE Y Y, et al. Relationship between serum inflammatory factors interleukin-18, high-sensitivity C-reactive protein, tumor necrosis factor-α and carotid atherosclerosis in patients with type 2 diabetes mellitus[J]. Journal of Clinical Internal Medicine, 2023, 40(4): 265-267.
    [8]
    中国医师协会皮肤科医师分会带状疱疹专家共识工作组, 国家皮肤与免疫疾病临床医学研究中心. 中国带状疱疹诊疗专家共识(2022版)[J]. 中华皮肤科杂志, 2022, 55(12): 1033-1040.

    Expert Consensus Working Group on Herpes Zoster, Dermatology Branch of Chinese Medical Doctor Association, National Clinical Research Center for Skin and Immune Diseases. Chinese expert consensus on diagnosis and treatment of postherpetic neuralgia[J]. Chinese Journal of Dermatology, 2022, 55(12): 1033-1040.
    [9]
    廖萌萌, 李亦梅, 席鹏, 等. 早期干预后带状疱疹后神经痛发生的高危因素及预测模型的建立[J]. 中华疼痛学杂志, 2023, 19(2): 236-241.

    LIAO M M, LI Y M, XI P, et al. High-risk factors for postherpetic neuralgia after early intervention and establishment of predictive model[J]. Chinese Journal of Pain Medicine, 2023, 19(2): 236-241.
    [10]
    MIYAZAWA H, WADA T. Immune-mediated inflammatory diseases with chronic excess of serum interleukin-18[J]. Front Immunol, 2022, 13: 930141. DOI: 10.3389/fimmu.2022.930141.
    [11]
    JU J, LI Z, JIA X Q, et al. Interleukin-18 in chronic pain: focus on pathogenic mechanisms and potential therapeutic targets[J]. Pharmacol Res, 2024, 201: 107089. DOI: 10.1016/j.phrs.2024.107089.
    [12]
    PAWLIK K, PIOTROWSKA A, KWIATKOWSKI K, et al. The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain[J]. Immunology, 2020, 159(4): 413-428.
    [13]
    LANDY E, CAROL H, RING A, et al. Biological and clinical roles of IL-18 in inflammatory diseases[J]. Nat Rev Rheumatol, 2024, 20(1): 33-47.
    [14]
    ZHU Y Y, ZHANG S P, WU Y B, et al. P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia[J]. Mol Cell Biochem, 2021, 476(9): 3461-3468.
    [15]
    LIANG X, FAN Y C. Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of interleukin-18 levels on postherpetic neuralgia risk[J]. Front Immunol, 2023, 14: 1183378. DOI: 10.3389/fimmu.2023.1183378.
    [16]
    LIU W H, HU H M, LI C, et al. Genetics of causal relationships between circulating inflammatory proteins and postherpetic neuralgia: a bidirectional Mendelian randomization study[J]. Front Neurol, 2024, 15: 1405694. DOI: 10.3389/fneur.2024.1405694.
    [17]
    DU J Y, SUN G L, MA H, et al. Prevalence and risk factors of anxiety and depression in patients with postherpetic neuralgia: a retrospective study[J]. Dermatology, 2021, 237(6): 891-895.
    [18]
    李娇, 黄国惠, 倪萍. 带状疱疹病人并发带状疱疹后神经痛的风险预测模型构建[J]. 护理研究, 2022, 36(18): 3239-3244.

    LI J, HUANG G H, NI P. Construction of risk prediction model for postherpetic neuralgia in patients with herpes zoster[J]. Journal of Nursing Research, 2022, 36(18): 3239-3244.
    [19]
    段苡文. 带状疱疹后遗神经痛危险因素的Meta分析[D]. 太原: 山西医科大学, 2019.

    DUAN Y W. Meta-analysis of risk factors for postherpetic neuralgia[D]. Taiyuan: Shanxi Medical University, 2019.
    [20]
    刘盼梅, 马民玉, 李寒冰, 等. 带状疱疹患者脑脊液中趋化因子水平与神经痛的相关性分析[J]. 中国基层医药, 2024, 31(8): 1183-1187.

    LIU P M, MA M Y, LI H B, et al. Correlation analysis of chemokine levels in cerebrospinal fluid of patients with herpes zoster and neuropathic pain[J]. China Basic Medical Journal, 2024, 31(8): 1183-1187.
    [21]
    吴征元, 杜佳溪, 孙悦, 等. 糖尿病对带状疱疹病人的预后影响及其危险因素研究[J]. 中国疼痛医学杂志, 2021, 27(4): 262-268.

    WU Z Y, DU J X, SUN Y, et al. Research on the impact of diabetes on the prognosis of herpes zoster patients and its risk factors[J]. Chinese Journal of Pain Medicine, 2021, 27(4): 262-268.
    [22]
    王颖, 赵伟, 张朝霞, 等. 建立和验证带状疱疹患者后遗神经痛风险因素预测模型[J]. 中国麻风皮肤病杂志, 2023, 39(4): 242-247.

    WANG Y, ZHAO W, ZHANG C X, et al. Establishment and validation of a risk factor prediction model for postherpetic neuralgia in patients with herpes zoster[J]. Chinese Journal of Leprosy and Dermatology, 2023, 39(4): 242-247.
    [23]
    王敏, 高静, 冯玫. 常见慢性病与带状疱疹相关性的研究进展[J]. 中华全科医师杂志, 2024, 23(4): 419-424.

    WANG M, GAO J, FENG M. Research progress on the correlation between common chronic diseases and herpes zoster[J]. Chinese General Practitioner Journal, 2024, 23(4): 419-424.
    [24]
    刘星, 樊碧发, 李怡帆, 等. 带状疱疹后神经痛发生的影响因素及临床预测模型构建[J]. 中国疼痛医学杂志, 2022, 28(2): 106-112.

    LIU X, FAN B F, LI Y F, et al. Influencing factors of postherpetic neuralgia and construction of clinical prediction model[J]. Chinese Journal of Pain Medicine, 2022, 28(2): 106-112.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (22) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return