Volume 23 Issue 6
Jun.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(6): 923-926
FAN Yuyun, WEI Junping, CHE Fengyuan. Analysis of causal relationship between gut microbiota and hyperthyroidism based on Mendelian randomization[J]. Chinese Journal of General Practice, 2025, 23(6): 923-926. doi: 10.16766/j.cnki.issn.1674-4152.004033
Citation: FAN Yuyun, WEI Junping, CHE Fengyuan. Analysis of causal relationship between gut microbiota and hyperthyroidism based on Mendelian randomization[J]. Chinese Journal of General Practice, 2025, 23(6): 923-926. doi: 10.16766/j.cnki.issn.1674-4152.004033
shu

Analysis of causal relationship between gut microbiota and hyperthyroidism based on Mendelian randomization

doi: 10.16766/j.cnki.issn.1674-4152.004033
  • 1.

    Department of Traditional Chinese Internal Medicine, Linyi People's Hospital, Linyi, Shandong 276000, China

Funds:

 82074412

 鲁卫人字〔2020〕3号

 鲁卫函〔2022〕233号

  • Received Date: 2024-12-26
    Available Online: 2025-09-04
    Abstract
  •   Objective  To investigate the relationship between human gut microbiota and hyperthyroidism.  Methods  The gut microbiota of the MiBioGen database was used as the exposure factor, and hyperthyroidism was used as the outcome variable. The GWAS data of hyperthyroidism were downloaded from the IEU Open GWAS database. Two-sample Mendelian randomization analysis was performed using regression models such as inverse variance weighting method, MR-Egger regression and weighted median method. The causal relationship between GM and intestinal flora was evaluated by β-value and odds ratio of effect index and so on. The stability and reliability of the results were verified by leave-one-out method, heterogeneity test and horizontal gene pleiotropic test.  Results  Mendelian randomization (MR) analysis revealed that, among 119 gut microbiota at the genus level, three bacterial taxa showed a negative association with hyperthyroidism: Dialister (OR=0.998, 95% CI: 0.996-1.000, P=0.037, β=-0.002), Escherichia. Shigella (OR=0.998, 95% CI: 0.996-1.000, P=0.032, β=-0.002), and Ruminococcaceae UCG014 (OR=0.998, 95% CI: 0.996-1.000, P=0.032, β=-0.002). All three genera exhibited β < 0, OR < 1, and P < 0.05, suggesting they may serve as protective factors against hyperthyroidism risk. The results of heterogeneity test (P>0.05), horizontal gene pleiotropic test (P>0.05) and sensitivity analysis proved that the formal results were reliable.  Conclusion  Dialister, Escherichia. Shigella and Ruminococcaceae UCG014 can reduce the risk of hyperthyroidism, the potential relationship between gut microbiota and hyperthyroidism is found preliminarily.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    中华医学会内分泌学分会, 中国医师协会内分泌代谢科医师分会, 中华医学会核医学分会, 等. 中国甲状腺功能亢进症和其他原因所致甲状腺毒症诊治指南[J]. 中华内分泌代谢杂志, 2022, 38(8): 700-748.

    Chinese Society of Endocrinology, Endocrinology and Metabolism Branch of Chinese Medical Doctor Association, Chinese Society of Nuclear Medicine, et al. Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis in China[J]. Chinese Journal of Endocrinology and Metabolism, 2022, 38(8): 700-748.
    [2]
    李雪彧, 刘庆阳. 甲状腺功能亢进症的治疗现状与展望[J]. 中外医学研究, 2022, 20(6): 170-172.

    LI X Y, LIU Q Y. Treatment status and prospect of hyperthyroidism[J]. Chinese and foreign medical research, 2022, 20(6): 170-172.
    [3]
    周文月, 梁家浩, 李泽豪, 等. 肠道菌群与抽动障碍的因果关联: 孟德尔随机化研究[J]. 华西医学, 2024, 39(8): 1195-1203.

    ZHOU W Y, LIANG J H, LI Z H, et al. Causal association between intestinal flora and tic disorder: Mendelian randomization study[J]. Huaxi Medicine, 2024, 39(8): 1195-1203.
    [4]
    杨璇, 李岩志, 马伟, 等. 基于两样本孟德尔随机化的肺功能与新型冠状病毒肺炎病死风险的因果关系[J]. 山东大学学报(医学版), 2021, 59(7): 104-111.

    YANG X, LI Y Z, MA W, et al. Causal relationship between lung function based on two-sample Mendelian randomization and mortality risk of COVID-19[J]. Journal of Shandong University(Medical Edition), 2021, 59(7): 104-111.
    [5]
    郑乾, 余彩遥, 李浩云, 等. 系统性红斑狼疮与重症肌无力: 一项双向孟德尔随机化研究[J]. 中华全科医学, 2024, 22(12): 2020-2024. doi: 10.16766/j.cnki.issn.1674-4152.003788

    ZHENG Q, YU C Y, LI H Y, et al. Systemic lupus erythematosus and myasthenia gravis : a two-way Mendelian randomized study[J]. Chinese Journal of General Practice, 2024, 22(12): 2020-2024. doi: 10.16766/j.cnki.issn.1674-4152.003788
    [6]
    SHIN H. XGBoost regression of the most significant photoplethysmogram features for assessing vascularaging[J]. IEEE J Biomed Health Inform, 2022, 26(7): 3354-3361.
    [7]
    李金菊, 杨浩, 阮诺冰, 等. 肠道菌群与糖尿病神经病变的因果关系: 双样本孟德尔随机化分析[J]. 中国微生态学杂志, 2024, 36(7): 761-768.

    LI J J, YANG H, RUAN N B, et al. Causal relationship between gut microbiota and diabetic neuropathy: two-sample Mendelian randomization analysis[J]. Chinese Journal of Microecology, 2024, 36(7): 761-768.
    [8]
    赵文生, 李孝林, 彭昌华, 等. 肠道菌群与骨质疏松性骨折[J]. 中国组织工程研究, 2025, 29(6): 1296-1304.

    ZHAO W S, LI X L, PENG C H, et al. Intestinal flora and osteoporotic fractures[J]. Chinese Tissue Engineering Research, 2025, 29(6): 1296-1304.
    [9]
    KURILSHIKOV A, MEDINA-GOMEZ C, BACIGALUPE R, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition[J]. Nat Genet, 2021, 53(2): 156-165.
    [10]
    YANG Y, XIAN W, WU D D, et al. The role of obesity, type 2 diabetes, and metabolic factors in gout: a Mendelian randomization study[J]. Front Endocrinol(Lausanne), 2022, 13(8): 917056. DOI: 10.3389/fendo.2022.917056.
    [11]
    陈继鑫, 周沁心, 郭天赐, 等. 白细胞介素-1受体拮抗剂与骨关节炎及亚型的孟德尔随机化研究[J]. 医学研究杂志, 2024, 53(4): 46-51.

    CHEN J X, ZHOU Q X, GUO T C, et al. Mendelian randomization study of interleukin-1 receptor antagonists and osteoarthritis and its subtypes[J]. Medical Research Journal, 2024, 53(4): 46-51.
    [12]
    黎征鹏, 章晓云, 武瑞骐, 等. 甲状腺功能障碍与骨质疏松症的因果关系: 双向两样本孟德尔随机化研究[J]. 华西医学, 2024, 39(10): 1617-1624.

    LI Z P, ZHANG X Y, WU R Q, et al. Causality between thyroid dysfunction and osteoporosis: a bidirectional two-sample Mendelian randomization study[J]. Huaxi Medicine, 2024, 39(10): 1617-1624.
    [13]
    XIANG K, WANG P, XU Z W, et al. Causal effects of gut microbiome on systemic lupus erythematosus: a two-sample Mendelian randomization study[J]. Front Immunol, 2021, 12(9): 667097. DOI: 10.3389/fimmu.2021.667097.
    [14]
    XUE Y, ZHANG L Z, CHEN Y J, et al. Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study[J]. Front Med, 2023, 10(6): 1174331. DOI: 10.3389/fmed.2023.1174331.
    [15]
    唐冬梅, 郭艳杰, 关怀, 等. 妊娠期合并甲状腺功能减退患者肠道菌群的研究[J]. 中国微生态学杂志, 2022, 34(2): 179-182.

    TANG D M, GUO Y J, GUAN H, et al. Study on intestinal flora in patients with hypothyroidism during pregnancy[J]. Chinese Journal of Microecology, 2022, 34(2): 179-182.
    [16]
    冯雨. 肠道菌群介导体液免疫参与Graves病的机制研究[D]. 郑州: 郑州大学, 2022.

    FENG Y. The mechanism of intestinal flora-mediated humoral immunity involved in Graves'disease[D]. Zhengzhou: Zhengzhou University, 2022.
    [17]
    李岩, 张宇霞, 单海燕. 基于两样本孟德尔随机化分析空腹血糖与冠心病的因果关系[J]. 中华全科医学, 2025, 23(1): 50-54. doi: 10.16766/j.cnki.issn.1674-4152.003833

    LI Y, ZHANG Y X, SHAN H Y. The causal relationship between fasting blood glucose and coronary heart disease was analyzed based on two-sample Mendelian randomization[J]. Chinese Journal of General Practice, 2025, 23(1): 50-54. doi: 10.16766/j.cnki.issn.1674-4152.003833
    [18]
    陈桂蓉, 宋锦彬, 潘丹旎, 等. 高校女性日常能耗与肠道菌群的相关性研究[J]. 中国微生态学杂志, 2024, 36(3): 255-263.

    CHEN G R, SONG J B, PAN D Y, et al. Study on the correlation between daily energy consumption and intestinal flora in college women[J]. Chinese Journal of Microecology, 2024, 36(3): 255-263.
    [19]
    廖驰真, 曾竣. 志贺菌流行耐药现状及溯源研究进展[J]. 中国卫生检验杂志, 2023, 33(16): 2046-2048.

    LIAO C Z, ZENG J. Research progress on epidemic resistance status and traceability of Shigella[J]. Chinese Journal of Health Inspection, 2023, 33(16): 2046-2048.
    [20]
    谭艳, 贾思锋, 左新河, 等. 从肠道微生物论健脾益气法治疗桥本甲状腺炎[J]. 中国微生态学杂志, 2024, 36(5): 617-621.

    TAN Y, JIA S F, ZUO X H, et al. Treatment of Hashimoto's thyroiditis with Jianpi Yiqi method from the perspective of intestinal microorganisms[J]. Chinese Journal of Microecology, 2024, 36(5): 617-621.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (15) PDF downloads(5) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return