Volume 23 Issue 6
Jun.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(6): 977-980
SUN Mingyue, GUO Pu, XIA Qun, PENG Wansheng. Effect of montelukast sodium on the efficacy of Mycoplasma pneumoniae pneumonia and cytokines[J]. Chinese Journal of General Practice, 2025, 23(6): 977-980. doi: 10.16766/j.cnki.issn.1674-4152.004046
Citation: SUN Mingyue, GUO Pu, XIA Qun, PENG Wansheng. Effect of montelukast sodium on the efficacy of Mycoplasma pneumoniae pneumonia and cytokines[J]. Chinese Journal of General Practice, 2025, 23(6): 977-980. doi: 10.16766/j.cnki.issn.1674-4152.004046
shu

Effect of montelukast sodium on the efficacy of Mycoplasma pneumoniae pneumonia and cytokines

doi: 10.16766/j.cnki.issn.1674-4152.004046
  • 1.

    Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2021A0761

 2023byzd085

  • Received Date: 2024-10-12
    Available Online: 2025-09-04
    Abstract
  •   Objective  In order to study how to treat Mycoplasma pneumoniae pneumonia (MPP) more effectively, montelukast sodium is added on the basis of anti-infection to study its effects on the efficacy of MPP and serum leukotrienes, interleukin 4 (IL-4), and interferon γ (IFN-γ), and to analyze the relationship between the above cytokines and MPP.  Methods  Ninety cases of children with MPP (57 mild cases, 33 severe cases) admitted to the First Affiliated Hospital of Bengbu Medical University from Aprial to December 2022 were selected and divided into a control group (anti-infective) and a study group (anti-infective add montelukast sodium) according to the single or double number of the order of admission on the day of hospitalization, with 45 cases in each group. The efficacy, adverse effects, and changes in cytokine levels before and after treatment between the two groups were compared, and the relationship between the above cytokines and the severity of MPP was compared.  Results  After 7 days of treatment, the study group showed lower scores in cough assessment, shorter fever resolution time, and reduced hospitalization duration compared to the control group. The clinical effectiveness rate was higher in the study group (43 cases, 95.5%) than in the control group (36 cases, 80.0%), with a statistically significant difference (P < 0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). After 7 days of treatment, both groups showed decreased serum levels of leukotrienes and IL-4 and increased IFN-γ levels compared to pre-treatment values (P < 0.05). Moreover, the study group exhibited significantly lower serum leukotriene and IL-4 levels and higher IFN-γ levels than the control group (P < 0.05). Patients with mild MPP had significantly lower serum leukotriene and IL-4 levels but higher IFN-γ levels compared to those with severe MPP (P < 0.05). Correlation analysis showed that the severity of MPP was positively correlated with the levels of serum leukotrienes and IL-4 (rs=0.725, 0.798, both P < 0.001), and negatively correlated with the level of IFN-γ (rs=-0.746, P < 0.001).  Conclusion  Montelukast sodium has good efficacy in treating MPP, which can regulate Th1/Th2 cytokine imbalance and has high safety. The severity of MPP is positively correlated with serum leukotriene and IL-4 levels, and negatively correlated with IFN-γ levels.

     

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