Advances in the correlation between HLA-B<sup>*</sup>27 subtypes and clinical phenotypes of spondyloarthritis

HUANG Yue; XU Congying; WANG Saisai; LI Yasong

doi:10.16766/j.cnki.issn.1674-4152.004056

Volume 23 Issue 6

Jun. 2025

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HUANG Yue, XU Congying, WANG Saisai, LI Yasong. Advances in the correlation between HLA-B*27 subtypes and clinical phenotypes of spondyloarthritis[J]. Chinese Journal of General Practice, 2025, 23(6): 1018-1021. doi: 10.16766/j.cnki.issn.1674-4152.004056

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HUANG Yue, XU Congying, WANG Saisai, LI Yasong. Advances in the correlation between HLA-B^*27 subtypes and clinical phenotypes of spondyloarthritis[J]. Chinese Journal of General Practice, 2025, 23(6): 1018-1021. doi: 10.16766/j.cnki.issn.1674-4152.004056

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Advances in the correlation between HLA-B^*27 subtypes and clinical phenotypes of spondyloarthritis

doi: 10.16766/j.cnki.issn.1674-4152.004056

HUANG Yue^{1, 2}
, XU Congying^{1, 2}
, WANG Saisai²
, LI Yasong^{2
,
,}

1.
The Second Clinical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

Funds:

GZY-ZJ-KJ-23047

2022KY052

Received Date: 2024-10-31
Available Online: 2025-09-04

Abstract

Abstract

Human leukocyte antigen HLA-B^*27 (B^*27) is closely associated with the development of spondyloarthritis (SpA). Different subtypes of B^*27 exhibit structural variations, which may contribute to differences in pathogenic mechanisms and clinical phenotypes. The correlation between B^*27 subtypes and SpA clinical phenotypes is as follows, (1) Among the 167 known subtypes of B^*27, approximately 16 are strongly associated with SpA. B^*2704 and B^*2705 are the most common subtypes in SpA patients, followed by B^*2702 and B^*2707. These subtypes exhibited greater protein misfolding at the molecular level compared to B^*2706 and B^*2709, which are less associated with SpA. (2) Characterization of SpA clinical forms with B^*27 subtypes: ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are primarily associated with B^*2704, whereas reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) are predominantly linked to B^*2705. Additionally, AS can present with double-positive B^*27 subtypes, and B^*2705, B^*2702 are mostly observed in Reiter ' s syndrome (RS). (3) Correlation between B^*27 subtypes and target organs of SpA: patients with B^*27 positivity are more likely to develop joint damage, uveitis, and cardiovascular complications than those without it. Patients with B^*2705 and B^*2702 are associated with early-onset hip ankylosis and enteritis, B^*2704 is linked to vision impairment and cardiovascular disease, and B^*2715 has a higher association with uveitis. Therefore, understanding the characteristics of different subtypes of clinical phenotypes is of great significance as a guide to the diagnosis and treatment of SpA.
- Spondyloarthritis,
- HLA-B^*27 subtype,
- Clinical phenotype,
- Correlation

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References(37)

References

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Advances in the correlation between HLA-B^*27 subtypes and clinical phenotypes of spondyloarthritis

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