Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1090-1093
LIN Lijuan, CHEN Guihai, SUN Huiqin, LI Chen, ZHANG Yemin. Clinical study of HF-rTMS combined with psychological behavioral intervention in the treatment of patients with chronic insomnia and comorbid anxiety and depression: based on polysomnography and brain functional status information[J]. Chinese Journal of General Practice, 2025, 23(7): 1090-1093. doi: 10.16766/j.cnki.issn.1674-4152.004071
Citation: LIN Lijuan, CHEN Guihai, SUN Huiqin, LI Chen, ZHANG Yemin. Clinical study of HF-rTMS combined with psychological behavioral intervention in the treatment of patients with chronic insomnia and comorbid anxiety and depression: based on polysomnography and brain functional status information[J]. Chinese Journal of General Practice, 2025, 23(7): 1090-1093. doi: 10.16766/j.cnki.issn.1674-4152.004071
shu

Clinical study of HF-rTMS combined with psychological behavioral intervention in the treatment of patients with chronic insomnia and comorbid anxiety and depression: based on polysomnography and brain functional status information

doi: 10.16766/j.cnki.issn.1674-4152.004071
  • 1.

    Department of Sleep Disorders, Chaohu Hospital, Anhui Medical University, Hefei, Anhui 238000, China

Funds:

 81671316

 2020xkj214

  • Received Date: 2025-02-11
    Available Online: 2025-10-25
    Abstract
  •   Objective   To explore the effects of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with psychological and behavioral intervention on subjective and objective sleep and brain functional status (BFS) in patients with chronic insomnia comorbidities of anxiety/depression.   Methods   Sixty patients with chronic insomnia comorbid with anxiety/depression in Chaohu Hospital Affiliated to Anhui Medical University from January 2023 to September 2024 were selected as the research subjects and randomly divided into a control group and an experimental group, with 30 cases in each group. Patients in the control group received psychological and behavioral intervention, while patients in the experimental group received psychological and behavioral intervention combined with HF-rTMS (10 Hz, 20 min each time, twice a day, for a total of 10 days). The changes of subjective and objective sleep, BFS, Hamilton anxiety scale (HAMA-14), and depression scale (HAMD-17) in the two groups before and after treatment were evaluated.   Results   (1) After treatment, the scores of HAMD-17 [6.50 (5.00, 8.00)], HAMA-14 [7.00 (6.00, 9.75)], and Arthas [5.00 (4.00, 7.00)] in the experimental group were all lower than those in the control group [10.50 (8.25, 12.00), 14.00 (9.25, 15.00), 10.00 (9.00, 12.75), P < 0.05]. (2) After treatment, the scores of brain chaos, internal concentration, drowsiness, brain inertia and brain fatigue in the experimental group were significantly lower than those in the control group, and the brain inhibition score was significantly higher than that in the control group (P < 0.05). (3) After treatment, the polysomnography indicators of the experimental group, such as total sleep time, sleep efficiency, and the proportion of non-rapid eye movement sleep phase Ⅲ (NREM3%), were significantly higher than those of the control group (P < 0.05). The latency to falling asleep, latency to falling asleep during the rapid eye movement phase, the awakening time after falling asleep, NREM1%, and the proportion of rapid eye movement sleep phase were all significantly lower than those in the control group (P < 0.05).   Conclusion   Psychological and behavioral intervention has an improvement effect on sleep quality, anxiety and depression in patients with chronic insomnia comorbidities of anxiety/depression. The combined treatment effect of HF-rTMS is more significant.

     

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