Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1115-1118
TANG Yajie, WANG Zhanyuan, SONG Lijie, LU Guoyu, LIU Cheng, TAO Yanyan. Predictive value of HBP, IL-18 combined with IL-6 for disease severity and prognosis in sepsis[J]. Chinese Journal of General Practice, 2025, 23(7): 1115-1118. doi: 10.16766/j.cnki.issn.1674-4152.004077
Citation: TANG Yajie, WANG Zhanyuan, SONG Lijie, LU Guoyu, LIU Cheng, TAO Yanyan. Predictive value of HBP, IL-18 combined with IL-6 for disease severity and prognosis in sepsis[J]. Chinese Journal of General Practice, 2025, 23(7): 1115-1118. doi: 10.16766/j.cnki.issn.1674-4152.004077
shu

Predictive value of HBP, IL-18 combined with IL-6 for disease severity and prognosis in sepsis

doi: 10.16766/j.cnki.issn.1674-4152.004077
  • 1.

    Emergency Medicine, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2023AH051996

 2021byzd157

 2022byzd039

  • Received Date: 2024-12-29
    Available Online: 2025-10-25
    Abstract
  •   Objective   Sepsis is associated with high mortality and rapid progression. To evaluate the prognosis and disease severity in septic patients, this study analyzed the expression levels of heparin-binding protein (HBP), interleukin (IL)-6, and IL-18 to explore their predictive value.   Methods   Eighty patients admitted to the Emergency Medicine Department and ICU of the First Affiliated Hospital of Bengbu Medical University from January 2023 to June 2024 were selected. According to the diagnostic criteria of sepsis, they were divided into the non-sepsis group, namely 20 cases in the common infection group, 35 cases in the sepsis group, and 25 cases in the septic shock group. The levels of HBP, IL-18 and IL-6 in the three groups of patients were compared. Taking 28 days as the endpoint of the study, patients with sepsis were divided into the survival group and the death group, and the levels of HBP, IL-18 and IL-6 in the two groups were compared. Pearson analysis was used to compare the correlations between HBP, IL-18, IL-6 and acute physiology and chronic health evaluation-Ⅱ score (APACHE-Ⅱ) score and sequential organ failure assessment (SOFA) score. The ROC curve was used to analyze the evaluation of the prognosis of patients with sepsis by HBP, IL-6 and IL-18.   Results   The HBP, IL-6 and IL-18 values of the common infection and septic group were significantly lower than the septic shock group (P < 0.001); the HBP, IL-6 and IL-18 values were significantly higher than the surviving group, respectively (P < 0.001). Moreover, HBP, IL-6 and IL-18 values showed significant positive correlation with SOFA score and APACHE-Ⅱ score. When HBP, IL-6 and IL-18 were tested separately, the area under the curve was 0.769, 0.793 and 0.818, respectively, and the Youden index was 0.460, 0.491 and 0.553, respectively. When the three indicators were tested jointly, the area under the ROC curve was 0.842 and the Youden index was 0.587, and the combined test value was higher than the single test value.   Conclusion   By comparing the serum levels of HBP, IL-6 and IL-18 in three groups, the severity of sepsis patients can be effectively reflected, and the combined detection of the three inflammatory factors has better evaluation efficiency than the single index alone.

     

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