Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1140-1143
ZHANG Bo, FAN Qin, GAO Chenggang, CAI Yuanchun, SHI Yonglong. The correlation between body mass index, systemic immune-inflammation index with the efficacy and prognosis of immunotherapy in NSCLC patients[J]. Chinese Journal of General Practice, 2025, 23(7): 1140-1143. doi: 10.16766/j.cnki.issn.1674-4152.004083
Citation: ZHANG Bo, FAN Qin, GAO Chenggang, CAI Yuanchun, SHI Yonglong. The correlation between body mass index, systemic immune-inflammation index with the efficacy and prognosis of immunotherapy in NSCLC patients[J]. Chinese Journal of General Practice, 2025, 23(7): 1140-1143. doi: 10.16766/j.cnki.issn.1674-4152.004083
shu

The correlation between body mass index, systemic immune-inflammation index with the efficacy and prognosis of immunotherapy in NSCLC patients

doi: 10.16766/j.cnki.issn.1674-4152.004083
  • 1.

    Department of Oncology, Ma'anshan Shiqiye Hospital, Ma'anshan, Anhui 243000, China

Funds:

 皖卫科教发〔2021〕273号-85

  • Received Date: 2025-03-22
    Available Online: 2025-10-25
    Abstract
  •   Objective  To investigate the correlation of body mass index (BMI) and systemic immunoinflammatory index (SII) with immunotherapy efficacy and prognosis in patients with non-small cell lung cancer (NSCLC), providing the theoretical basis for individualized clinical treatment.  Methods  A total of 140 patients with NSCLC admitted to Ma ' anshan Shiqiye Hospital and Ma ' anshan People ' s Hospital from August 2021 to August 2022 were retrospectively included. Patients were separated into low BMI group (BMI＜25, n=108) and high BMI group (BMI≥25, n=32) based on baseline BMI value, and were separated into low SII group (SII＜642.40, n=70) and high SII group (SII≥642.40, n=70) based on baseline median SII value as the boundary. The correlation of BMI and SII with immunotherapy efficacy of patients was analyzed, and the patients were followed up for two years to analyze the survival prognosis of patients. Cox regression analysis was used to explore the factors affecting the survival prognosis of patients with NSCLC.  Results  The objective remission rate (ORR) at the end of immunotherapy cycle in low BMI group was lower [45.37% (49/108) vs. 75.00% (24/32), χ2=8.685, P=0.003], and ORR was lower in the high SII group than the low SII group [37.14% (26/70) vs. 67.14% (47/70), χ2=12.623, P < 0.001]. After two years of follow-up, the median follow-up time was (12.07±3.45) months. The median progression-free survival (PFS) in patients with BMI < 25, adrenal metastasis, liver metastasis, and SII≥642.40 was lower than that in patients with BMI < 25, no adrenal metastasis and liver metastasis, and SII < 642.40, respectively (P < 0.05). Cox regression analysis showed that BMI < 25, adrenal metastasis, liver metastasis and SII≥642.40 were all risk factors for the median PFS in NSCLC patients (P < 0.05).  Conclusion  Both BMI and SII are closely related to immunotherapy efficacy in patients with NSCLC and are risk factors for poor prognosis.

     

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