Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1176-1179
ZHONG Lixia, LI Zhulin, MA Ruoyun, JI Binbin, ZHAO Juanjuan, LIN Xiaoling. Latent class analysis of childhood trauma in patients with bipolar disorder and its relationship with resilience and functional outcomes[J]. Chinese Journal of General Practice, 2025, 23(7): 1176-1179. doi: 10.16766/j.cnki.issn.1674-4152.004091
Citation: ZHONG Lixia, LI Zhulin, MA Ruoyun, JI Binbin, ZHAO Juanjuan, LIN Xiaoling. Latent class analysis of childhood trauma in patients with bipolar disorder and its relationship with resilience and functional outcomes[J]. Chinese Journal of General Practice, 2025, 23(7): 1176-1179. doi: 10.16766/j.cnki.issn.1674-4152.004091
shu

Latent class analysis of childhood trauma in patients with bipolar disorder and its relationship with resilience and functional outcomes

doi: 10.16766/j.cnki.issn.1674-4152.004091
  • 1.

    School of Nursing, Sun Yat-sen University, Guangzhou, Guangdong 510080, China

Funds:

 71904213

  • Received Date: 2024-10-28
    Available Online: 2025-10-25
    Abstract
  •   Objective  To explore latent classes of childhood trauma in patients with bipolar disorder (BD) and to examine the mediating effects of resilience in the relationship between latent classes and functional outcomes (psychosocial functioning and quality of life).  Methods  A total of 272 inpatients and outpatients with BD were recruited by convenience sampling from the Third Affiliated Hospital of Sun Yat-sen University and Guangzhou Huiai Hospital between September 2019 and April 2021. Participants were assessed by general information questionnaire, childhood trauma questionnaire short form, conner-davidson resilience scale, functioning assessment short test, 12 items short form health survey, 17-item Hamilton depression rating scale, and Young mania rating scale. Latent class analysis was used to explore the latent classes of childhood trauma, and covariance analysis was used to compare resilience and functional outcomes among patients with different latent classes of childhood trauma. Mediation analysis was used to investigate the mediating role of resilience between latent classes of childhood trauma and functional outcomes.  Results  Three distinct trauma classes were identified: "low trauma" (n=152, 55.9%), "high neglect" (n=48, 17.6%), and "high trauma" (n=72, 26.5%). The latent classes had a significant main effect on resilience, social function, and quality of life (F=8.173, 3.599, 4.800, all P < 0.001). Using the "low trauma" class as the reference, the mediating effects of resilience in the "high neglect" class on psychosocial function and quality of life were 0.21 (95% CI: 0.08 to 0.34) and -0.21 (95% CI: -0.34 to -0.09), respectively.  Conclusion  The childhood trauma among patients with bipolar disorder is heterogeneous. Identifying childhood trauma profiles and providing targeted intervention based on trauma characteristics and resilience levels may help improve the functional outcomes in patients.

     

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