Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1209-1213
CHEN Jingyi, GAO Fankai, XUE Guofang. Advancements in the study of tight junction protein-5 in epilepsy within the blood-brain barrier[J]. Chinese Journal of General Practice, 2025, 23(7): 1209-1213. doi: 10.16766/j.cnki.issn.1674-4152.004099
Citation: CHEN Jingyi, GAO Fankai, XUE Guofang. Advancements in the study of tight junction protein-5 in epilepsy within the blood-brain barrier[J]. Chinese Journal of General Practice, 2025, 23(7): 1209-1213. doi: 10.16766/j.cnki.issn.1674-4152.004099
shu

Advancements in the study of tight junction protein-5 in epilepsy within the blood-brain barrier

doi: 10.16766/j.cnki.issn.1674-4152.004099

  • Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China

Funds:

 202203021212056

  • Received Date: 2025-01-23
    Available Online: 2025-10-25
    Abstract
  • The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells. It is an important protective barrier that can limit the entry of harmful substances in the blood into the brain and maintain a stable internal environment of brain tissue. Its integrity is crucial to brain function. Tight junction proteins are key components in maintaining the structure and function of the BBB. These proteins are located between brain microvascular endothelial cells, connecting adjacent cells, and maintaining barrier integrity, forming a highly regulated microenvironment. Claudin-5 is one of the most abundant tight junction proteins in the BBB and is widely distributed on the cell membrane of brain microvascular endothelial cells. Studies have shown that Claudin-5 plays a crucial role in regulating the integrity and permeability of the BBB. It ensures the selective permeability of the BBB by controlling the connection gaps between cells, allowing the brain to obtain the required oxygen, glucose, and other substances, while preventing harmful substances, pathogens, and other potentially harmful substances from entering the brain. Once the expression or function of Claudin-5 becomes abnormal, the function of BBB will be affected, thus triggering a series of nervous system diseases, such as neuroinflammation, cerebrovascular disease and neurodegenerative diseases. Epilepsy is a disease caused by abnormal neural discharges. Some studies have shown that Claudin-5 may be involved in the pathogenesis of epilepsy by changing the permeability of the BBB and affecting the ion concentration in the brain tissue. Although the specific mechanism is not fully understood at present, changes in Claudin-5 may be closely related to the occurrence of epilepsy. In summary, Claudin-5 not only plays a vital role in maintaining the integrity of the BBB, but also has potential research value in the pathogenesis of central nervous system diseases, especially epilepsy. This article will review the physiological functions, pathological changes, and role of Claudin-5 in maintaining BBB integrity and epilepsy, providing new ideas for the treatment of epilepsy.

     

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