Volume 23 Issue 7
Jul.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(7): 1222-1226
LI Zhishen, WANG Dai, GUO Ruitong, AN Jing, HE Manman. The efficacy of Jianpi Huatan Formula combined with acupuncture in the treatment of post-stroke depression and its influence on serum renin-angiotensin system[J]. Chinese Journal of General Practice, 2025, 23(7): 1222-1226. doi: 10.16766/j.cnki.issn.1674-4152.004102
Citation: LI Zhishen, WANG Dai, GUO Ruitong, AN Jing, HE Manman. The efficacy of Jianpi Huatan Formula combined with acupuncture in the treatment of post-stroke depression and its influence on serum renin-angiotensin system[J]. Chinese Journal of General Practice, 2025, 23(7): 1222-1226. doi: 10.16766/j.cnki.issn.1674-4152.004102
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The efficacy of Jianpi Huatan Formula combined with acupuncture in the treatment of post-stroke depression and its influence on serum renin-angiotensin system

doi: 10.16766/j.cnki.issn.1674-4152.004102

  • Department of Encephalopathy, Shijiazhuang Hospital of Traditional Chinese Medicine (Shijiazhuang Hospital), Shijiazhuang, Hebei 050000, China

Funds:

 2021270

  • Received Date: 2024-09-06
    Available Online: 2025-10-25
    Abstract
  •   Objective  To investigate the curative effect of Jianpi Huatan Formula combined with acupuncture on post-stroke depression (PSD) and to analyze its mechanism from the aspect of serum renin-angiotensin system (RAS).  Methods  A total of 150 patients diagnosed with PSD were treated at Shijiazhuang Hospital of Traditional Chinese Medicine from June 2021 to December 2023. These patients methodically divided into three groups for the purpose of this study: a decoction group (n=50, Jianpi Huatan Formula oral), an acupuncture group (n=50) and a combined group (n=50, Jianpi Huatan Formula + acupuncture). The randomization method was employed to ensure the equitable distribution of subjects across the three groups. A comparison was made of the therapeutic effect, scores before and after treatment, and serum neurotransmitters [5-hydroxytryptamine (5-HT), substance P (SP), brain-derived neurotrophic factor (BDNF), retinol-binding protein 4 (RBP4)] and RAS [plasma renin activity (PRA), angiotensin (Ang) Ⅱ, Ang 1-7] were compared among the three groups.  Results  A statistically significant disparity was observed in the total effective rate among the three groups [47 cases (94.0%) vs. 38 cases (76.0%) vs. 36 cases (72.0%), χ2=8.806, P=0.012]. The total TCM syndrome score, Hamilton depression scale (HAMD) -17, National Institutes of Health stroke scale (NIHSS) score, serum SP, RBP4, plasma PRA and Ang Ⅱ levels were significantly lower in the combined group after four weeks of treatment than in the other two groups (P < 0.05), while activity of daily living (ADL) score, serum 5-HT, BDNF, Ang 1-7 levels were significantly higher (P < 0.05). No statistically significant difference was found in various indexes between the decoction group and the acupuncture group (P>0.05). The investigation revealed no statistically significant difference in adverse reactions among the three groups (P>0.05).  Conclusion  The combination of Jianpi Huatan Formula and acupuncture has been demonstrated to be both safe and effective in the treatment of PSD. The potential mechanisms underlying this efficacy include regulation of the RAS and neurotransmitters.

     

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