Volume 23 Issue 9
Sep.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(9): 1496-1498
ZHAO Shasha, WANG Pengwei, WANG Yuanyuan, FENG Xianjun. Prognostic value of IL-33 expression in alveolar lavage fluid for predicting 28-day mortality in elderly patients with severe pneumonia[J]. Chinese Journal of General Practice, 2025, 23(9): 1496-1498. doi: 10.16766/j.cnki.issn.1674-4152.004163
Citation: ZHAO Shasha, WANG Pengwei, WANG Yuanyuan, FENG Xianjun. Prognostic value of IL-33 expression in alveolar lavage fluid for predicting 28-day mortality in elderly patients with severe pneumonia[J]. Chinese Journal of General Practice, 2025, 23(9): 1496-1498. doi: 10.16766/j.cnki.issn.1674-4152.004163
shu

Prognostic value of IL-33 expression in alveolar lavage fluid for predicting 28-day mortality in elderly patients with severe pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.004163

  • Respiratory ICU, the First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, China

Funds:

 LHGJ20210525

  • Received Date: 2024-09-18
    Available Online: 2025-11-17
    Abstract
  •   Objective  Previous studies had shown a close association between the inflammatory status of severe pneumonia and serum interleukin 33 (IL-33) levels. However, the prognostic significance of IL-33 levels in alveolar lavage fluid was still unclear. This study aimed to investigate the relationship between expression levels of IL-33 in alveolar lavage fluid and 28-day mortality in elderly patients with severe pneumonia and its prognosis.  Methods  A total of 160 elderly patients with severe pneumonia admitted to the Respiratory ICU of the First Affiliated Hospital of Xinxiang Medical University between January 2021 and December 2023 were enrolled. Based on 28-day survival status, patients were divided into a survival group (n=117) and a death group (n=43). The clinical data of all individuals were collected, and the expression levels of IL-33 in alveolar lavage fluid were analyzed by ELISA methods. Pearson method was used to analyze the correlation between IL-33 levels and acute physiology and chronic health evaluation-Ⅱ score (APACHE Ⅱ) of elderly patients with severe pneumonia. The clinical efficacy of IL-33 levels in predicting 28-day mortality in elderly patients with severe pneumonia was analyzed by ROC curve.  Results  Compared with the survival group, the levels of leukocytes, neutrophils, hypersensitive C-reactive protein, procalcitonin, and APACHE Ⅱ in the death group were significantly increased than in the survival group, respectively (P < 0.05). The expression level of IL-33 in alveolar lavage fluid in the death group was significantly higher than that in the survival group (P < 0.001). The expression level of IL-33 in alveolar lavage fluid of elderly patients with severe pneumonia was positive correlated with APACHE Ⅱ score (r=0.671, P < 0.001). The procalcitonin and IL-33 in alveolar lavage fluid were identified as independent risk factors for 28-day treatment for severe pneumonia. The expression level of IL-33 in alveolar lavage fluid of elderly patients with severe pneumonia had a significant clinical efficacy in predicting 28-day mortality, with sensitivity and specificity of 89.45% and 90.82%, respectively.  Conclusion  The expression level of IL-33 in alveolar lavage fluid was significantly increased in elderly patients with severe pneumonia. IL-33 may serve as a biomarker for predicting 28-day mortality in this population.

     

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