Volume 23 Issue 9
Sep.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(9): 1512-1515
LI Weiwei, WANG Lu, PAN Yourang, CHEN Jing. Clinical study of Tricobacterium bifidum capsule combined with escitalopram oxalate in the treatment of adult first episode depression[J]. Chinese Journal of General Practice, 2025, 23(9): 1512-1515. doi: 10.16766/j.cnki.issn.1674-4152.004167
Citation: LI Weiwei, WANG Lu, PAN Yourang, CHEN Jing. Clinical study of Tricobacterium bifidum capsule combined with escitalopram oxalate in the treatment of adult first episode depression[J]. Chinese Journal of General Practice, 2025, 23(9): 1512-1515. doi: 10.16766/j.cnki.issn.1674-4152.004167
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Clinical study of Tricobacterium bifidum capsule combined with escitalopram oxalate in the treatment of adult first episode depression

doi: 10.16766/j.cnki.issn.1674-4152.004167

  • Department One of Psychosomatic Medicine (Sleep Ward), Shaoxing Seventh People' s Hospital, Shaoxing, Zhejiang 312000, China

Funds:

 2023KY1272

  • Received Date: 2025-01-01
    Available Online: 2025-11-17
    Abstract
  •   Objective  The microbial-gut-brain axis (MGB) theory provides a new perspective for the treatment of depression. This study was to investigate the effect of living bacteria capsule of Tricobacterium bifidum combined with commonly used antidepressants in the treatment of adult first-episode depression.  Methods  A total of 126 adult patients with first-episode depression admitted to the Department of Psychosomatic Medicine of Shaoxing Seventh People ' s Hospital from April 2023 to October 2024 were randomly divided into a control group (escitalopram oxalate alone) and a study group (Tricobacterium bifidum live capsules combined with escitalopram oxalate) for 12 weeks (n=63 each). The score and reduction rate of Hamilton depression-17 (HAMD-17) scale, intestinal flora detection in fresh stool, relevant biochemical indicators [interleukin-6 (IL-6), 5-hydroxytryptamine (5-HT)], clinical efficacy, and treatment safety were compared.  Results  Fifty-eight cases in the control group and 60 cases in the study group completed the study. The HAMD-17 scores decreased significantly in both groups at 4, 8, and 12 weeks (P < 0.05). The HAMD-17 scores of the study group at 8 and 12 weeks were lower than those of the control group (P < 0.05). The reduction rate of HAMD-17 was higher in the study group [(53.93±5.81)% vs. (36.69±5.17)%, t=17.042, P < 0.05] after 12 weeks of treatment, with superior overall efficacy (P < 0.05). After 12 weeks of treatment, the Lactobacillus count, Bifidobacterium count, B/E value (0.89±0.16 vs. 0.74±0.13), and serum 5-HT level in the study group were higher than those in the control group (P < 0.05), while the Enterococcus count, Enterobacter count, and serum IL-6 in the study group were lower than those in the control group (P < 0.05). No significant difference was observed in the adverse reaction rates between the two groups (P>0.05).  Conclusion  In adult patients with first-episode depression, Bifidobacterium live capsule combined with escitalopram oxalate can significantly improve intestinal flora balance, regulate serum IL-6 and 5-HT levels, and improve clinical benefits without increasing adverse effects.

     

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