Volume 23 Issue 9
Sep.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(9): 1531-1534
QIAN Xiaoting, SHAO Lei, ZHANG Jun. Clinical efficacy of allergen-specific immunotherapy in Children with allergic rhinitis and its correlation with Treg cell levels[J]. Chinese Journal of General Practice, 2025, 23(9): 1531-1534. doi: 10.16766/j.cnki.issn.1674-4152.004171
Citation: QIAN Xiaoting, SHAO Lei, ZHANG Jun. Clinical efficacy of allergen-specific immunotherapy in Children with allergic rhinitis and its correlation with Treg cell levels[J]. Chinese Journal of General Practice, 2025, 23(9): 1531-1534. doi: 10.16766/j.cnki.issn.1674-4152.004171
shu

Clinical efficacy of allergen-specific immunotherapy in Children with allergic rhinitis and its correlation with Treg cell levels

doi: 10.16766/j.cnki.issn.1674-4152.004171
  • 1.

    Department of Pharmacy, Chun' an Branch of Zhejiang Provincial People' s Hospital, Hangzhou, Zhejiang 311700, China

Funds:

 2023XY014

  • Received Date: 2024-08-18
    Available Online: 2025-11-17
    Abstract
  •   Objective   Allergen-specific immunotherapy (ASIT) is a novel desensitization therapy for allergic diseases. However, its efficacy may be influenced by the immune response levels in children. Therefore, this study aimed to evaluated the clinical efficacy of ASIT in the treatment of allergic rhinitis and to investigate its correlation with Treg cell levels.   Methods   A total of 100 children with allergic rhinitis who were treated at Chun' an Branch of Zhejiang Provincial People' s Hospital from January to November 2020 were enrolled. According to their treatment willingness, the children were divided into an observation group receiving allergen-specific immunotherapy and a control group receiving conventional treatment, with 50 cases in each group. The clinical efficacy, lung function, allergen-specific immunoglobulin E level (sIgE), and peripheral blood Treg cell level were compared between the two groups. The Pearson correlation coefficient was used to analyze the correlation between the levels of peripheral Treg cell and the treatment efficacy.   Results   At the end of treatment, 1 month and 3 month after treatment, the total nasal symptom score (TNSS) in the observation group was lower than that in the control group. The levels of CD4+CD25+Foxp3+ Treg cells in the observation group [(8.54±1.07)%, (8.56±1.12)%, (8.79±1.33)%] were higher than those in the control group [(8.00±1.15)%, (8.05±1.32)%, (8.03±1.17)%, P < 0.05]. At both 1 month and 3 months post-treatment, the sIgE levels in the observation group were lower than those in the control group (P < 0.05). However, there was no statistically significant difference in the predicted percentage of forced expiratory volume in 1 second (FEV1% pred) between the two groups (P>0.05). In the observation group, the TNSS score at 3 months post-treatment completion was negatively correlated with the level of Treg cells (r=-0.469, P < 0.05), whereas no significant correlation was observed in the control group (P>0.05).   Conclusion   Subcutaneous allergen-specific immunotherapy is effective in improving clinical symptoms in children with allergic rhinitis, as evidenced by reduced serum sIgE levels, and increased peripheral blood Treg cell levels. Furthermore, the clinical efficacy is negatively correlated with Treg cell levels.

     

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    • References(20)
  • [1]
    孟娟, 徐睿, 叶菁, 等. 变应性鼻炎的分类和诊断专家共识(2022, 成都)[J]. 中国眼耳鼻喉科杂志, 2022, 22(3): 215-224.

    MENG J, XU R, YE J, et al. Expert consensus on classification and diagnosis of allergic rhinitis(2022, Chengdu)[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2022, 22(3): 215-224.
    [2]
    中国医师协会变态反应医师分会, 中国医师协会儿科医师分会耳鼻咽喉专业委员会, 中国人体健康科技促进会儿童变态反应分会. 儿童过敏性鼻炎阶梯治疗中国专家共识[J]. 中华预防医学杂志, 2022, 56(9): 1182-1189.

    Allergy Branch of Chinese Medical Doctor Association; Otolaryngoyogy Group, Society of Pediatrics, Chinese Medical Doctor Association; Child Allergy Professional Committee, China Association for Promotion of Health Science and Technology. Chinese expert consensus on stepwise treatment of pediatric allergic rhinitis[J]. Chinese Journal of Preventive Medicine, 2022, 56(9): 1182-1189.
    [3]
    WISE S K, DAMASK C, ROLAND L T, et al. International consensus statement on allergy and rhinology: allergic rhinitis-2023[J]. Int Forum Allergy Rhinol, 2023, 13(4): 293-859. doi: 10.1002/alr.23090
    [4]
    LAYHADI J A, LALIOTI A, PALMER E, et al. Mechanisms and predictive biomarkers of allergen immunotherapy in the clinic[J]. J Allergy Clin Immunol Pract, 2024, 12(1): 59-66. doi: 10.1016/j.jaip.2023.11.027
    [5]
    杜文锦, 张秋兴, 张文超, 等. 郑州地区成人自报过敏性鼻炎患者吸入过敏原分析[J]. 中华全科医学, 2022, 20(10): 1675-1677, 1804. doi: 10.16766/j.cnki.issn.1674-4152.002676

    DU W J, ZHANG Q X, ZHANG W C, et al. Sensitization patterns of inhaled allergens in adults self-reported allergic rhinitis in Zhengzhou area[J]. Chinese Journal of General Practice, 2022, 20(10): 1675-1677, 1804. doi: 10.16766/j.cnki.issn.1674-4152.002676
    [6]
    YANG Y, LI W, ZHU R. Allergen immunotherapy in China[J]. Front Allergy, 2023, 4: 1324844. DOI: 10.3389/falgy.2023.1324844.
    [7]
    黄荷花, 许翀, 刘璐, 等. 标准化屋尘螨变应原皮下特异性免疫治疗对单一与多重过敏的变应性鼻炎患者的疗效比较和安全性分析[J]. 中华预防医学杂志, 2022, 56(6): 774-783.

    HUANG H H, XU C, LIU L, et al. Efficacy comparison and safety analysis of subcutaneous specific immunotherapy with standardized house dust mite allergen in patients with single and multiple allergic rhinitis[J]. Chinese Journal of Preventive Medicine, 2022, 56(6): 774-783.
    [8]
    LINTON S, BURROWS A G, HOSSENBACCUS L, et al. Future of allergic rhinitis management[J]. Ann Allergy Asthma Immunol, 2021, 127(2): 183-190. doi: 10.1016/j.anai.2021.04.029
    [9]
    PFAAR O, PORTNOY J, NOLTE H, et al. Future directions of allergen immunotherapy for allergic rhinitis: experts' perspective[J]. J Allergy Clin Immunol Pract, 2024, 12(1): 32-44. doi: 10.1016/j.jaip.2023.08.047
    [10]
    中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组、小儿学组. 儿童变应性鼻炎诊断和治疗指南(2022年, 修订版)[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(4): 392-404.

    Subspecialty Group of Rhinology, Editorial Baord of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Groups of Rhinology and Pediatrics, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Aassociation. Guideline for diagnosis and treatment of pediatric allergic rhinitis (2022, revision)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(4): 392-404.
    [11]
    DURHAM S R, SHAMJI M H. Allergen immunotherapy: past, present and future[J]. Nat Rev Immunol, 2023, 23(5): 317-328. doi: 10.1038/s41577-022-00786-1
    [12]
    RATTANAMANEE T, LUMJIAKTASE P, KEMAWICHANURA N, et al. Immunologic changes after house dust mite modified rush subcutaneous immunotherapy in allergic rhinitis children[J]. Asia Pac Allergy, 2022, 12(1): e4. DOI: 10.5415/apallergy.2022.12.e4.
    [13]
    SU Q, REN N, FENG M, et al. Specific immunoglobulin G4 correlates with Th2 cytokine reduction in patients with allergic asthma treated by dermatophagoides pteronyssinus subcutaneous immunotherapy[J]. World Allergy Organ J, 2023, 16(1): 100715. DOI: 10.1016/j.waojou.2022.100715.
    [14]
    XIAN M, FENG M, DONG Y, et al. Changes in CD4+CD25+FoxP3+ Regulatory T cells and serum cytokines in sublingual and subcutaneous immunotherapy in allergic rhinitis with or without asthma[J]. Int Arch Allergy Immunol, 2020, 181(1): 71-80. doi: 10.1159/000503143
    [15]
    RATTANAMANEE T, LUMJIAKTASE P, KEMAWICHANURA N, et al. Regulatory T cell and cytokine changes in children undergoing 3 days rush venom immunotherapy[J]. Asian Pac J Allergy Immunol, 2023, 41(3): 193-198.
    [16]
    YANG L, YANG Y, XU Q, et al. Specific IgE and IgG4 profiles of house dust mite components in allergen-specific immunotherapy[J]. Front Immunol, 2021, 12: 786738. DOI: 10.3389/fimmu.2021.786738.
    [17]
    DARLAN D M, MUNIR D, PUTRA A, et al. MSCs-released TGFβ1 generate CD4+CD25+Foxp3+ in T-reg cells of human SLE PBMC[J]. J Formos Med Assoc, 2021, 120(1 Pt 3): 602-608.
    [18]
    VICTOR J R, NAHM D H. Mechanism underlying polyvalent IgG-induced regulatory T cell activation and its clinical application: anti-idiotypic regulatory T cell theory for immune tolerance[J]. Front Immunol, 2023, 14: 1242860. DOI: 10.3389/fimmu.2023.1242860.
    [19]
    KLEIN M, PLANTE S, BOULAY M È, et al. Discrepancy in the suppressive function of regulatory T cells in allergic asthmatic vs. allergic rhinitis subjects upon low-dose allergen challenges[J]. Front Allergy, 2023, 4: 1296601. DOI: 10.3389/falgy.2023.1296601.
    [20]
    QIAO Y L, JIAO W E, XU S, et al. Allergen immunotherapy enhances the immunosuppressive effects of Treg cells to alleviate allergic rhinitis by decreasing PU-1+Treg cell numbers[J]. Int Immunopharmacol, 2022, 112: 109187. DOI: 10.1016/j.intimp.2022.109187.
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