Volume 29 Issue 10
Oct.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(10): 1672-1675
DAI Rong, HAN Shu, XIE Weinan, WANG Baojia, DI Jiamei. Effects of serum HIF-1α and VEGF on vascular calcification in patients with maintenance hemodialysis[J]. Chinese Journal of General Practice, 2025, 23(10): 1672-1675. doi: 10.16766/j.cnki.issn.1674-4152.004202
Citation: DAI Rong, HAN Shu, XIE Weinan, WANG Baojia, DI Jiamei. Effects of serum HIF-1α and VEGF on vascular calcification in patients with maintenance hemodialysis[J]. Chinese Journal of General Practice, 2025, 23(10): 1672-1675. doi: 10.16766/j.cnki.issn.1674-4152.004202
shu

Effects of serum HIF-1α and VEGF on vascular calcification in patients with maintenance hemodialysis

doi: 10.16766/j.cnki.issn.1674-4152.004202
  • 1.

    Graduate School of Bengbu Medical University, Bengbu, Anhui 233030, China

Funds:

 AHWJ2023A 10030

 YZ2023H1B004

  • Received Date: 2024-09-19
    Abstract
  •   Objective  To investigate the relationship between serum hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), and vascular calcification (VC) in patients with maintenance hemodialysis (MHD), and to evaluate their predictive value for VC.  Methods  A total of 101 patients with chronic kidney disease (CKD) who underwent MHD in the Blood Purification Center of the First Affiliated Hospital of Anhui University of Science and Technology from October 2023 to August 2024 were enrolled. The patients ' VC was evaluated by abdominal lateral X-ray. According to the abdominal aortic calcification score (AACS), they were divided into a calcification group (59 cases) and a non-calcification group (42 cases). The clinical data, such as serum calcium and phosphorus, and serum HIF-1α and VEGF levels, were compared between the two groups. The correlation method was used to analyze the correlation between HIF-1α, VEGF, and AACS. Multivariate logistic regression was used to analyze the influencing factors of VC in MHD patients. The ROC curve was used to analyze the predictive value of HIF-1α and VEGF levels for VC in MHD patients.  Results  The age, dialysis age, alkaline phosphatase, serum calcium, serum phosphorus, TC, HIF-1α, and VEGF levels in the calcification group were higher than those in the non-calcification group (P < 0.05). Correlation analysis showed that the levels of HIF-1α and VEGF were positively correlated with AACS (P < 0.05). Multivariate logistic regression showed that age, serum calcium, serum phosphorus, HIF-1α, and VEGF were risk factors for VC in MHD patients (P < 0.05). The areas under the ROC curves of HIF-1α and VEGF alone and their combined prediction were 0.756 (sensitivity 47.5%, specificity 97.6%), 0.777 (sensitivity 71.2%, specificity 76.2%), and 0.879 (sensitivity 83.1%, specificity 83.3%), respectively.  Conclusion  Age, serum calcium, serum phosphorus, and levels of HIF-1α and VEGF are important influencing factors for the occurrence of VC in MHD patients. HIF-1α and VEGF are positively correlated with AACS. Both have certain predictive value for the occurrence of VC in MHD patients, and the combined predictive value is higher.

     

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