Volume 29 Issue 10
Oct.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(10): 1681-1684
MENG Shasha, LI Nan, LIU Xiaohua. The expression of NLPR3 and NF-κB in peripheral blood mononuclear cells of patients with diabetic cardiomyopathy and their correlation with myocardial perfusion[J]. Chinese Journal of General Practice, 2025, 23(10): 1681-1684. doi: 10.16766/j.cnki.issn.1674-4152.004204
Citation: MENG Shasha, LI Nan, LIU Xiaohua. The expression of NLPR3 and NF-κB in peripheral blood mononuclear cells of patients with diabetic cardiomyopathy and their correlation with myocardial perfusion[J]. Chinese Journal of General Practice, 2025, 23(10): 1681-1684. doi: 10.16766/j.cnki.issn.1674-4152.004204
shu

The expression of NLPR3 and NF-κB in peripheral blood mononuclear cells of patients with diabetic cardiomyopathy and their correlation with myocardial perfusion

doi: 10.16766/j.cnki.issn.1674-4152.004204
  • 1.

    Department of Vascular Surgery, Qingdao Municipal Hospital of Rehabilitation University, Qingdao, Shandong 266000, China

Funds:

 202203010192

  • Received Date: 2025-03-11
    Abstract
  •   Objective  To explore nucleotide-binding oligomerization domain-like receptor protein 3(NLPR3) in peripheral blood mononuclear cells of patients with diabetic cardiomyopathy (DCM) Expression characteristics of nuclear transcription factor KappaB(NF-κB) and its correlation with myocardial perfusion development in patients.  Methods  A total of 100 patients with diabetes admitted to Qingdao Hospital of University of Health and Rehabilitation Sciences from June 2023 to June 2024 were enrolled and divided into a DCM group and a diabetes group. An additional 30 healthy individuals undergoing physical examinations were selected as the control group. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of NLPR3 and NF-κB expression in DCM. Pearson correlation was used to analyze the correlation between NLPR3 and NF-κB expression with summed stress score (SSS score) and summed rest score (SRS score) on myocardial perfusion.  Results  The expressions levels of NLPR3 and NF-κB in the DCM group (1.67±0.28, 2.21±0.65) were higher than those in the diabetes group (1.04±0.20, 1.57±0.38), and both were elevated relative to the control group (0.76±0.10, 0.75±0.10; F=172.319, 91.669, P < 0.05). The areas under the curve of NLPR3, NF-κB, and their combined detection for diagnosing DCM were 0.963, 0.847, and 0.990, respectively (P < 0.05). The SSS and SRS scores of the DCM group (19.68±8.19, 13.10±4.62) were both higher than those in the diabetes group (6.36±1.04, 5.21±1.92), while the LVEF [(34.14±15.58) %] was lower than that in the diabetes group [(53.21±8.58)%, t=12.877, 11.980, 7.907, P < 0.05]. The expressions of NLPR3 and NF-κB in patients with DCM were positively correlated with SSS and SRS scores (r=0.449, 0.367, 0.353, 0.401, P < 0.05).  Conclusion  NLPR3 and NF-κB are upregulated in peripheral blood mononuclear cells of DCM patients, and their expression is closely associated with impaired myocardial perfusion. These markers can assist the clinical diagnosis of DCM and provide insights into the pathophysiological mechanisms of DCM.

     

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