The expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke and their relationship with prognosis

DUAN Kaiqiang; WU Yanfeng; XUE Jiahai; WANG Wei; LI Chunling; LI Juan

doi:10.16766/j.cnki.issn.1674-4152.004209

Volume 29 Issue 10

Oct. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(10): 1701-1705

DUAN Kaiqiang, WU Yanfeng, XUE Jiahai, WANG Wei, LI Chunling, LI Juan. The expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke and their relationship with prognosis[J]. Chinese Journal of General Practice, 2025, 23(10): 1701-1705. doi: 10.16766/j.cnki.issn.1674-4152.004209

Citation:

DUAN Kaiqiang, WU Yanfeng, XUE Jiahai, WANG Wei, LI Chunling, LI Juan. The expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke and their relationship with prognosis[J]. Chinese Journal of General Practice, 2025, 23(10): 1701-1705. doi: 10.16766/j.cnki.issn.1674-4152.004209

Citation:

DUAN Kaiqiang, WU Yanfeng, XUE Jiahai, WANG Wei, LI Chunling, LI Juan. The expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke and their relationship with prognosis[J]. Chinese Journal of General Practice, 2025, 23(10): 1701-1705. doi: 10.16766/j.cnki.issn.1674-4152.004209

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The expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke and their relationship with prognosis

doi: 10.16766/j.cnki.issn.1674-4152.004209

1.
Emergency Department, Zhangjiakou First Hospital, Zhangjiakou, Hebei 075000, China

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20221896

Received Date: 2025-02-24

Abstract

Abstract

Objective By detecting the expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke (AIS), aimed to further explore their relationship with the patient ' s condition and prognosis. Methods From February 2022 to February 2024, 179 patients with AIS admitted to Zhangjiakou First Hospital were selected as the observation group, and divided into a mild group of 59 cases, a moderate group of 75 cases, and a severe group of 45 cases, and 179 healthy individuals who underwent physical examinations at our hospital were regarded as the control group. According to the patient ' s prognosis, they were divided into a good prognosis group 132 cases and a poor prognosis group 47 cases. The correlation between serum miR-760-3p and miR-182-5p expression levels and NIHSS score, the prognostic factors of patients with AIS, and the predictive value of serum miR-760-3p and miR-182-5p for the prognosis of patients with AIS were analyzed. Results The expression levels of miR-760-3p and miR-182-5p in the observation group and poor prognosis group were lower than those in the control group and good prognosis group, respectively (P < 0.05). As the severity of the disease deepens, the expression levels of miR-760-3p and miR-182-5p in the patient ' s serum decreased sequentially (P < 0.05). The expression levels of serum miR-760-3p and miR-182-5p were negatively correlated with NIHSS scores (r_s=-0.578, -0.618, P < 0.001). The age, smoking history, hypertension history, and serum miR-760-3p and miR-182-5p were influencing factors for poor prognosis in patients with AIS (P < 0.05). ROC curve results showed that the AUC of their combination in predicting the prognosis of AIS patients was higher than that of miR-760-3p and miR-182-5p alone (P < 0.05). Conclusion The downregulation of miR-760-3p and miR-182-5p expression in the serum of AIS patients was closely related to prognosis.
- Acute ischemic stroke,
- miR-760-3p,
- miR-182-5p,
- Prognosis

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The expression of serum miR-760-3p and miR-182-5p in patients with acute ischemic stroke and their relationship with prognosis

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