Volume 29 Issue 10
Oct.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(10): 1709-1712
YOU Jinbiao, XU Chan, XU Lei, ZHANG Qifan. Study on the clinical effect and mechanism of Shengyang Yiwei Decoction in regulating intestinal microflora to improve spleen deficiency type 2 diabetes[J]. Chinese Journal of General Practice, 2025, 23(10): 1709-1712. doi: 10.16766/j.cnki.issn.1674-4152.004211
Citation: YOU Jinbiao, XU Chan, XU Lei, ZHANG Qifan. Study on the clinical effect and mechanism of Shengyang Yiwei Decoction in regulating intestinal microflora to improve spleen deficiency type 2 diabetes[J]. Chinese Journal of General Practice, 2025, 23(10): 1709-1712. doi: 10.16766/j.cnki.issn.1674-4152.004211
shu

Study on the clinical effect and mechanism of Shengyang Yiwei Decoction in regulating intestinal microflora to improve spleen deficiency type 2 diabetes

doi: 10.16766/j.cnki.issn.1674-4152.004211

  • Clinical Laboratory, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, China

Funds:

 2022ZB201

  • Received Date: 2024-09-17
    Abstract
  •   Objective  To explore the clinical efficacy of Shengyang Yiwei Decoction on type 2 diabetes mellitus (T2DM) patients with spleen deficiency, and discuss the correlation between its mechanism and intestinal flora.  Methods  Adhering closely to specific criteria, we enrolled 60 patients at the Third Affiliated Hospital of Zhejiang Chinese Medical University from September 2022 to August 2023 diagnosed with spleen deficiency-related T2DM and randomized them into two groups of 30 each using random number table method. The control group was administered standard Western therapy, including oral hypoglycemic drugs or insulin injections, on this basis, the experimental group was treated with Shengyang Yiwei Decoction, with a treatment cycle of 8 weeks. The changes in fasting plasma glucose (FPG), 2-hour post-load blood glucose (2hPG), glycated hemoglobin A1c (HbA1c) levels were detected by blood indicators, the changes in intestinal microbiota were detected using the 16S rDNA method, and the clinical curative effect was evaluated by the integral change of traditional Chinese medicine (TCM) syndrome.  Results  (1) The total effective rate of the experimental group patients after treatment was (90.00%, 27/30), which was higher than that of the control group (66.67%, 20/30, χ2=4.812, P=0.028), the score of TCM syndrome was lower than that of the control group (P < 0.01). (2) Both groups experienced significant decreases in FPG, 2hPG, and HbA1c levels after treatment, with the experimental group showing lower levels than the control group (P < 0.01). (3) Alpha diversity and Beta diversity analysis revealed that the experimental group showed a greater increase in species richness and diversity compared to the control group after treatment (P < 0.05), with significant differences in intestinal microbiota structure. Among them, the abundance of Proteus, Morchella, and Klebsiella increased significantly (P < 0.05).  Conclusion  Shengyang Yiwei Decoction is effective in improving blood glucose indicators and TCM syndrome manifestations of spleen deficiency type T2DM, with its mechanism being related to regulating intestinal flora disorders.

     

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