Volume 29 Issue 10
Oct.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(10): 1764-1767
E Yuan, HUANG Shengchang, RUI Lining. The clinical study of Bushen Huoxue Decoction combined with unilateral biportal endoscopy (UBE) in the treatment of lumbar spinal stenosis with kidney deficiency and blood stasis[J]. Chinese Journal of General Practice, 2025, 23(10): 1764-1767. doi: 10.16766/j.cnki.issn.1674-4152.004224
Citation: E Yuan, HUANG Shengchang, RUI Lining. The clinical study of Bushen Huoxue Decoction combined with unilateral biportal endoscopy (UBE) in the treatment of lumbar spinal stenosis with kidney deficiency and blood stasis[J]. Chinese Journal of General Practice, 2025, 23(10): 1764-1767. doi: 10.16766/j.cnki.issn.1674-4152.004224
shu

The clinical study of Bushen Huoxue Decoction combined with unilateral biportal endoscopy (UBE) in the treatment of lumbar spinal stenosis with kidney deficiency and blood stasis

doi: 10.16766/j.cnki.issn.1674-4152.004224

  • Department of Orthopedics, Wujin Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu 213100, China

Funds:

 QN202221

 QN202246

  • Received Date: 2025-02-24
    Abstract
  •   Objective  To evaluate the effects of Bushen Huoxue Decoction combined with unilateral biportal endoscopy (UBE) in patients with lumbar spinal stenosis (LSS) of kidney deficiency and blood stasis, focusing on recovery, inflammatory response, and postoperative complications, and to explore the therapeutic effect of integrated Chinese and Western medicine.  Methods  From June 2023 to April 2024, 120 patients with kidney deficiency and blood stasis type LSS were enrolled at Wujin Hospital of Traditional Chinese Medicine, Changzhou, and randomly divided into a treatment group (Bushen Huoxue Decoction + UBE) and a control group (UBE alone). The indicators such as visual analogue scale (VAS) score, Oswestry disability index (ODI) score, changes of serum interferon-γ (IFN-γ)/ interleukin-1α (IL-1α) were assessed.  Results  The treatment group demonstrated a higher overall response rate compared with the control group [86.67% (52/60) vs. 71.67% (43/60), χ2=4.093, P=0.043]. The VAS score in the treatment group was lower than that in the control group at 2 weeks and 1 month postoperatively (P < 0.05), while ODI score was lower at 1 and 6 months (P < 0.05). After treatment, serum IFN-γ and IL-1α levels in peripheral blood were significantly reduced in the treatment group compared with the control group (P < 0.05). The incidence of postoperative complications was also lower in the treatment group [6.67% (4/60) vs. 23.33% (14/60), χ2=6.536, P=0.011].  Conclusion  Bushen Huoxue Decoction combined with UBE can significantly improve the efficacy of kidney deficiency and blood stasis type LSS, reduce postoperative VAS and ODI scores, decrease serum IFN-γ and IL-1α levels, and reduce the risk of postoperative complications, supporting its value as an integrated therapeutic strategy.

     

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    • References(20)
  • [1]
    丁恒, 胡乐, 李由, 等. UBE术式与常规开放手术治疗腰椎间盘突出症的临床和放射学结果分析[J]. 昆明医科大学学报, 2024, 45(9): 62-69.

    DING H, HU L, LI Y, et al. Analysis of clinical and radiological outcomes between UBE procedure and conventional open surgery in the treatment of Lumbar Disc Herniation[J]. Journal of Kunming Medical University, 2024, 45(9): 62-69.
    [2]
    芦怀旺, 田霖, 胡鹏, 等. 单侧双通道内镜治疗单责任节段腰椎管狭窄症的短期临床疗效分析[J]. 中华全科医学, 2023, 21(3): 413-416. doi: 10.16766/j.cnki.issn.1674-4152.002896

    LU H W, TIAN L, HU P, et al. Short-term clinical effect analysis of unilateral biportal endoscopic surgery for of single responsible segment lumbar spinal stenosis[J]. Chinese Journal of General Practice, 2023, 21(3): 413-416. doi: 10.16766/j.cnki.issn.1674-4152.002896
    [3]
    吴昊, 于海洋, 翟云雷, 等. 椎间隙环Cage周围270°自体骨回植术对腰椎融合术后椎体融合率及疗效的影响[J]. 中华全科医学, 2021, 19(9): 1488-1491. doi: 10.16766/j.cnki.issn.1674-4152.002093

    WU H, YU H Y, ZHAI Y L, et al. Effect of 270° autogenous bone replantation around the intervertebral cage on vertebral fusion rate and efficacy after lumbar fusion[J]. Chinese Journal of General Practice, 2021, 19(9): 1488-1491. doi: 10.16766/j.cnki.issn.1674-4152.002093
    [4]
    赵庆瑞, 钟远鸣, 付小鹏, 等. 中医药治疗腰椎管狭窄症的研究进展[J]. 西部中医药, 2024, 37(8): 87-92.

    ZHAO Q R, ZHONG Y M, FU X P, et al. Research progress in TCM therapy for lumbar spinal stenosis[J]. West J Tradit Chin Med, 2024, 37(8): 87-92.
    [5]
    周彦吉, 安易, 雷园, 等. 中医综合方案干预退行性腰椎管狭窄症的临床研究[J]. 世界科学技术-中医药现代化, 2023, 25(6): 2188-2195.

    ZHOU Y J, AN Y, LEI Y, et al. A Clinical study on the intervention of a comprehensive program of traditional Chinese medicine on degenerative lumbar spinal stenosis[J]. World Sci Technol-Moderniz Tradit Chin Med, 2023, 25(6): 2188-2195.
    [6]
    程宏亮, 周静珠. 邵氏"补肾活血"方结合四指推法治疗肾虚血瘀型腰椎间盘突出症的临床研究[J]. 现代中西医结合杂志, 2023, 32(4): 460-464, 469.

    CHENG H L, ZHOU J Z. Clinical study on Shao's "tonifying kidney and activating blood" decoction combined with four finger massage in the treatment of lumbar disc herniation with syndrome of kidney deficiency and blood stasis[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2023, 32(4): 460-464, 469.
    [7]
    王镇远, 冯帅华, 李泽湘, 等. 补肾活血汤对大鼠腰椎间盘退行性变模型Fas/FasL信号通路的影响[J]. 湖南中医药大学学报, 2023, 43(3): 430-436.

    WANG Z Y, FENG S H, LI Z X, et al. Effects of Bushen Huoxue Decoction on Fas/FasL signaling pathway of lumbar intervertebral disc degeneration rat model[J]. J Tradit Chin Med Univ Hunan, 2023, 43(3): 430-436.
    [8]
    世界中医药学会联合会骨质疏松专业委员会, 上海中医药大学附属龙华医院, 中日友好医院, 等. 腰椎管狭窄症中西医结合诊疗专家共识[J]. 世界中医药, 2023, 18(7): 936-944.

    Osteoporosis Professional Committee of the World Federation of Chinese Medicine Societies, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China-Japan Friendship Hospital, etc. Expert Consensus on Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Lumbar Spinal Stenosis[J]. World Chin Med, 2023, 18(7): 936-944.
    [9]
    魏戌, 徐卫国, 李路广, 等. 腰椎管狭窄症中西医结合诊疗指南(2023年)[J]. 中国全科医学, 2024, 27(25): 3076-3082, 3099.

    WEI S, XU W G, LI L G, et al. Guidelines for Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Lumbar Spinal Stenosis (2023)[J]. Chinese Journal of General Practice, 2024, 27(25): 3076-3082, 3099.
    [10]
    安易, 陈红, 王锡友, 等. 中医综合方案干预中重度腰椎管狭窄症的新思路[J]. 中国医药导报, 2022, 19(32): 130-132, 137.

    AN Y, CHEN H, WANG X Y, et al. A New approach to the intervention of moderate to severe Lumbar Spinal stenosis with a comprehensive Traditional Chinese Medicine program[J]. Chin Med Herald, 2022, 19(32): 130-132, 137.
    [11]
    D'ERCOLE M, INNOCENZI G, LATTUADA P, et al. Does Laminectomy Affect Spino-Pelvic Balance in Lumbar Spinal Stenosis? A Study Based on the EOS X-Ray Imaging System[J]. Acta Neurochir Suppl, 2023, 135(1): 405-412.
    [12]
    HATAKKA J, LAAKSONEN I, KOSTENSALO J, et al. 1-year results of lumbar spinal stenosis surgery in Finland: a national FinSpine register study[J]. Acta Orthop, 2025, 96(1): 154-160.
    [13]
    徐朝栋, 王传兵, 尤涛. 老年退行性腰椎管狭窄症患者术后并发下腰痛影响因素[J]. 中国老年学杂志, 2023, 43(5): 1120-1122.

    XU Z D, WANG C B, YOU T. Influencing factors of postoperative low back pain in elderly patients with degenerative lumbar spinal stenosis[J]. Chinese Journal of Gerontology, 2023, 43(5): 1120-1122.
    [14]
    占允中, 杨帆, 叶舟, 等. 单侧双通道内镜治疗重度腰椎管狭窄症的近期疗效分析[J]. 浙江医学, 2024, 46(12): 1300-1304.

    ZHAN Y Z, YANG F, YE Z, et al. Short-term efficacy of unilateral dual channel endoscopy in the treatment of severe lumbar spinal stenosis[J]. Zhejiang Medical J, 2024, 46(12): 1300-1304.
    [15]
    康健, 王世轩. 中医外治法治疗腰椎管狭窄症的研究进展[J]. 实用中医内科杂志, 2022, 36(1): 97-99.

    KANG J, WANG S X. Research Progress on Treatment of Lumbar Spinal Stenosis with External Therapy of Traditional Chinese Medicine[J]. J Pract Tradit Chin Intern Med, 2022, 36(1): 97-99.
    [16]
    董胜, 黄文茁, 吴时桢, 等. 补阳还五汤联合OLIF-PIVOX系统治疗腰椎椎管狭窄症随机对照研究[J]. 中国中西医结合杂志, 2023, 43(12): 1427-1432.

    DONG S, HUANG W Z, WU S Z, et al. Effect of Buyang Huanwu Decoction combined with OLIF-PIVOX system on lumbar spinal stenosis: a randomized controlled trial[J]. Chin J Integr Tradit West Med, 2023, 43(12): 1427-1432.
    [17]
    郭心鸽, 姚欣艳, 刘侃, 等. 国医大师熊继柏辨治腰痛的临床经验[J]. 湖南中医药大学学报, 2021, 41(7): 982-985.

    GUO X G, YAO X Y, LIU K, et al. Master of Chinese Medicine Xiong Jibo's Clinical Experience in Differentiating and Treating Low Back Pain[J]. J Tradit Chin Med Univ Hunan, 2021, 41(7): 982-985.
    [18]
    赵灿斌, 付仔祥, 王凤铭, 等. 基于网络药理学、分子对接和实验验证研究续断散加当归、骨碎补调控PI3K/AKT信号通路治疗激素性股骨头坏死的潜在机制[J]. 世界中西医结合杂志, 2023, 18(7): 1366-1374.

    ZHAO C B, FU Z X, WANG F M, et al. Study on potential mechanism of teasel root sanjia angelica sinensis and drynaria rhizome regulating PI3K/AKT signal pathway to treat steroid-induced femoral head necrosis based on network pharmacology, molecular docking, and experimental verification[J]. World J Integr Tradit West Med, 2023, 18(7): 1366-1374.
    [19]
    赵翔凤, 相光鑫, 石丛薇, 等. 基于方剂构成信息的知识发现和关联网络构建挖掘海洋中药海马历代用药经验[J]. 世界科学技术-中医药现代化, 2021, 23(2): 335-343.

    ZHAO X F, XIANG GX, SHI C W, et al. Exploration of marine traditional Chinese medicine experience in the use of hippocampus through the ages based on knowledge discovery and associative network construction of formulary composition information[J]. World Sci Technol-Moderniz Tradit Chin Med, 2021, 23(2): 335-343.
    [20]
    邱翔, 潘磊, 楚永杰, 等. 活血补肾汤辅助治疗骨质疏松性胸腰椎压缩性骨折患者的短期随访研究[J]. 辽宁中医杂志, 2024, 51(6): 78-81.

    QIU X, PAN L, CHU Y J, et al. Short-term follow-up study on auxiliary treatment of patients with OVCF after treatment with Huoxue Bushen Decoction[J]. Liaoning J Tradit Chin Med, 2024, 51(6): 78-81.
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