Visualization analysis of research literature on TCM regulation of tumor microenvironment

DONG Huijing; ZHENG Yumin; LI Jia; LU Xingyu; CUI Huijuan

doi:10.16766/j.cnki.issn.1674-4152.004228

Volume 29 Issue 10

Oct. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(10): 1781-1785

DONG Huijing, ZHENG Yumin, LI Jia, LU Xingyu, CUI Huijuan. Visualization analysis of research literature on TCM regulation of tumor microenvironment[J]. Chinese Journal of General Practice, 2025, 23(10): 1781-1785. doi: 10.16766/j.cnki.issn.1674-4152.004228

Citation:

DONG Huijing, ZHENG Yumin, LI Jia, LU Xingyu, CUI Huijuan. Visualization analysis of research literature on TCM regulation of tumor microenvironment[J]. Chinese Journal of General Practice, 2025, 23(10): 1781-1785. doi: 10.16766/j.cnki.issn.1674-4152.004228

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Visualization analysis of research literature on TCM regulation of tumor microenvironment

doi: 10.16766/j.cnki.issn.1674-4152.004228

1.
Beijing University of Chinese Medicine, China-Japan Friendship Clinical Medical College, Beijing 100029, China

Funds:

2022-NHLHCRF-LX-02-0111

2022-2-4065

Received Date: 2024-09-18

Abstract

Abstract

Objective The tumor microenvironment has been a critical focus in cancer research. This study employs visualization methods to systematically analyze the current research landscape and highlight key areas of interest concerning the regulation of the tumor microenvironment by traditional Chinese medicine. The objective is to elucidate its primary mechanisms and clinical applications. Methods A comprehensive literature search was conducted across various databases including CNKI, Wanfang Data, VIP, CBM, and WOS, with the search period ending on March 22, 2024. NoteExpress was used for literature screening, GraphPad Prism was employed to chart annual publication trends, VOSviewer was used for analyzing authors and keywords and creating author co-occurrence networks and keyword time networks, and CiteSpace was used for keyword clustering analysis. Results A total of 690 documents were included in the study. The earliest publication was recorded in 2005, with a significant increase in publications observed since 2018. High-frequency publishing journals include 'China Journal of Traditional Chinese Medicine and Pharmacy', 'Journal of Traditional Chinese Medicine', 'Chinese Journal of Experimental Traditional Medical Formulas', 'Journal of Ethnopharmacology', and 'Fronyiers in Pharmacology'. The Chinese-language publications included a total of 1 766 authors, while English-language publication included a total of 1 443 authors. A total of 9 Chinese and 11 English keyword clusters were identified, with major themes centering on mechanisms of action and clinical applications. Conclusion Visual analysis found that TCM regulates the tumor microenvironment by pathways including tumor angiogenesis, inflammation, exosomes, autophagy, apoptosis, and macrophage polarization. TCM has been widely applied in the treatment of various cancer types, including breast, lung, liver, colorectal, and gastric cancers.
- Traditional Chinese medicine,
- Tumor microenvironment,
- Visual analysis,
- Bibliometrics,
- VOSviewer,
- CiteSpace

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References(27)

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Visualization analysis of research literature on TCM regulation of tumor microenvironment

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Visualization analysis of research literature on TCM regulation of tumor microenvironment

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