Evaluating the diagnostic value of some related index for children with severe measles combined pneumonia by ROC curve

Objective To explore the clinical features of children with measles combined pneumonia,and evaluate the severity-related indicators by the ROC curve. Methods The clinical data of 62 children with measles combined pneumonia in our hospital were reviewed.The patients were divided into severe group(n=15)and the control group(n=47)according to the condition.The fasting venous blood within 24 h after the admission was prepared for the test of WBC,NE%,PLT,CRP,IgM,IgA,IgG were tested with immunoturbidimetric assay,LDH with enzymatic method,and albumin with bromocresol green method.The clinical characteristics and laboratory indexes of both groups were compared with single factor analysis,and the ROC curve for the indicators which had statistical difference. Results The history of measles vaccination,WBC,NE%,PLT,IgM,IgA,IgG between the two groups had no statistical differences.The course prior to the admission in the severe pneumonia group was 10.0(5.0,15.0)d which was longer than that in the control group[6.0(3.0,10.0)d];the duration of fever of children was 11.0(8.0,16.0)d which was longer than that in the control group[7.0(3.0,9.0)d](P＜0.05);the CRP was 17.0(4.0,50.0)mg/L which was higher than that in the control group[6.0(1.0,13.0)mg/L],LDH was 433.0(373.0,601.0)U/L which was higher than that in the control group[352.0(277.0,427.0)U/L],P＜0.05.The AUC(area under the ROC curve) of the course prior to admission,duration of fever,CRP,LDH were 0.689,0.784,0.723 and 0.731,respectively;the critical value was 9,7.5 d,25.5 mg/L and 366.0 U/L,respectively;the sensitivity was 60.0%,93.3%,73.3% and 86.7%,respectively;and the specific degrees was 74.5%,57.4%,68.1% and 59.6%,respectively;95%CI was 0.547-0.830,0.657-0.911,0.566-0.881,0.587-0.876,respectively. Conclusions The course prior to admission,duration of fever,CRP,LDH are the related indicators.The patients whose course prior to admission,long duration of fever and high levels of CRP and LDH are easily to present severe measles combined with pneumonia.The lower diagnostic value of the course prior to admission was lower for measles combined with severe pneumonia,and the duration of fever,levels of CRP and LDH has medium diagnostic value.