Effectiveness of concurrent chemoradiation with Cisplatin or Nedaplatin for locally advanced cervical cancer

Objective To explore the effect and safty of concurrent chemoradiationwith Cisplatin(CDDP)or Nedaplatin(NDP)in treatment of locally advanced Cervical cancer(CC). Methods Total 72 patients with advanced CC undergoing concurrent chemoradiation in our hospital from May 2013 to July 2014 were selected.36 cases in the observation group were given NDP treatment for 3 months(40 mg/m² weekly,until the external lighting end),while 36 cases in the control group were given CDDP treatment for 3 months(40 mg/m² weekly,until the external lighting end),one times a week,total 5 weeks.The effect was evaluated according to the Evaluation Criteria in Solid Tumors(UICC),and 1-year survivl rate,transfer rate,recurrence rate and adverse reactions were followed up. Results The remission rate was 94.4%(34/36)in the observation group,while was 72.2%(26/36)in the control group,the remission rate in the observation group was obviously higher than that of the control group(χ²=6.400,P<0.05);1-year survival rate,transfer rate and recurrence rate in the observation group were 91.7%(33/36),5.6%(2/36)and 8.3%(3/36),while in the control group was 86.1%(31/36),25.0%(9/36)and 33.3%(12/36),1-year transfer rate and recurrence rate in the observation group was obviously better than that in the control group(χ²=5.258/6.821,P<0.05);the incidence of low white blood cell count(Ⅲ-Ⅳ),low platelets,nausea,vomiting and diarrhea in the control group was significantly higher than those in the observation group(P<0.05). Conclusion The concurrent chemoradiationwith Cisplatin(CDDP)or Nedaplatin(NDP)in treatment of locally advanced Cervical cancer(CC)has a good short-term effect,with lower incidence of adverse reactions,worthy of further promotion in clinical practice.