Associations of ulcerative colitis with Bsm Ⅰ,Apa Ⅰ and Taq Ⅰ polymorphisms in vitamin D receptor gene

Objective To investigate the associations between VDR gene(Bsm-Ⅰ,Apa-Ⅰ and Taq-Ⅰ) polymorphisms and ulcerative colitis(UC) in a Chinese Population. Methods Total 198 cases of UC and 312 normal subjects were recruited.VDR Bsm Ⅰ,Apa Ⅰ and Taq Ⅰ polymorphisms was genotyped with direct sequencing.Haplotype analysis was conducted using Haploview 4.2. Results The allelic and genotypic frequencies of VDR(Bsm I,Apa I,Taq I) did not statistically differ between UC patients and the controls (all P＞0.05).The haplotype analysis showed that the Bsm I,Apa I and Taq I polymorphic loci were in a strong linkage disequilibrium.In addition,the frequency of AAC haplotype in UC patients was significantly lower than in the controls[3.53%(14/396) vs 7.21%(45/624),P=0.014,OR=0.472,95%CI:0.255-0.871]. Conclusion Individuals with AAC haplotype formed by VDR(Bsm Ⅰ,Apa Ⅰ,Taq Ⅰ)might have a lower risk of UC.