Correlation between CT perfuson parameters and expression of vascular endothelial growth factor in Laryngeal cancer

Objective To observe the correlation between the CT perfusion parameters and the expression of vascular endothelial growth factor(VEGF)in lesions of laryngeal cancer. Methods Twenty-three lesions of laryngeal cancer were scanned by spiral CT,and the perfusion parameters were calculated with perfusion functional software.The parameters included blood flow(BF),blood volume(BV),mean transit time(MTT)and permeability surface(PS).Histopathological slides were prepared for the VEGF immunohistochemical staining.Correlation between the CT perfusion parameters and VEGF was studed. Results ①Between benign and malignant lesions of laryngeal cancer with CT perfusion parameters(BF,BV,MTT and PS)was difference.BF of malignant tumor was higher than that of benign lesions(P＜0.05).②In laryngeal cancer,BF and BV was positively correlated with VEGF(r=0.502,0.327,P＜0.05),MTT and VEGF showed a negative correlation (r=-0.511,P＜0.05),there was not correlative between PS and VEGF(r=0.275,P＞0.05). Conclusion CT perfusion parameters of laryngeal cancer is correlated with the level of VEGF,which may reflect the expresion of VEGF.The CT perfusion should be helpful to diagnosis and treatment laryngeal cancer.