Effect of low dose ketamine on sleep of patients with postpartum depression

Objective To evaluate the effect of low dose ketamine onpolysomnography(PSG),pitsburgh sleep qualityindex(PSQI) and edinburgh postnatal depression scale(EPDS) of patients with postpartum depression(PPD). Methods Sixty EPDS≥10 patients were divided randomly into 2 groups(n=30 each):ketamine group (group K) and normal saline group(group N).The patients in group K were intravenously administrated 0.6 mg/kg ketamine.The patients in group N were intravenously administrated normal saline.The EPDS,PSG and PSQI of patients were determined before treated(T0),two days(T1) after treated,and four days after treated(T2). Results Compared with group N,the TST and SE of patients in group K were increasedat T1 and T2(P<0.05);Compared with group N,the SIP,REM,RIP and AN of patients in group K were decreased at T1 and T2(P<0.05).Compared with group N,the PSQI and EPDS of patients in group K were decreased at T1 and T2(P<0.05).Compared with T0,the TST and SE of patients in group K were increasedat T1 and T2(P<0.05);Compared with T0,the SIP,REM,RIP and AN of patients in group K were decreased at T1 and T2(P<0.05).Compared with T0,the PSQI and EPDS of patients in group K were decreased at T1 and T2(P<0.05). Conclusion Low dose ketamine could significantly improved sleep quality of patients with PPD.