Comparison of BASDAI and ASDAScrp in a measure of disease activity in patients with spondyloarthropathy

Objective To compare the differences and clinical significance of Bath ankylosing spondylitis disease activity index (BASDAI) and Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-crp) in the assessment of disease activity in patients with spondyloarthritis (Sp A). Methods A total of 177 patients with Sp A were recruited.The disease activity in Sp A were calculated by BASDAI and ASDAScrp and subsequently divided into clinical remission and disease activity according to BASDAI scoring standard,or clinical remission,low-moderate activity,high activity,very high activity according to ASDAScrp scoring standard. Results 1 One hundred and twenty-nine patients which accounted for 72.9% in all 177 patients were defined as remission stage according to BASDAI standard,and 48(27.1%) patients were categorized as disease activity.Out of 121 patients who had valid ASDAScrp scores,22(18.2%) patients were classified into remission stage,23(19.0%) patients into low-moderate active stage,53(43.8%) patients into high active stage and 23(19.0%) patients into very high activity,whilst according to ASDAScrp standard.There were significant differences between BASDAI and ASDAScrp in assessing disease activity (χ²=47.050,P<0.001),the consistency index was 0.454.Variables of ASDAScrp score,BASDAI score,BPC,ESR,CRP,PGA and BASFI in patients with ASDAScrp remission were significantly lower than that in patients with BASDAI remission (P<0.05).2 Percentage of SPARCC>0 in ASDAScrp active patients was clearly higher than that in ASDAScrp remission patient (χ²=12.903,P<0.001),while median of SPARCC score was also obvious higher than that in the latter group (z=3.477,P=0.001).No differences were found between patients with BASDAI remission and active patients (P>0.05).3 ASDAScrp positively correlated with BASDAI in Sp A (r=0.795,P<0.001).There were positive linear correlations between BASDAI/ASDAScrp and PGA,swollen joint count,tender joint count,occipital wall distance,finger-floor distance,BASFI,BPC,ESR,CRP and SPARCC scoring (P<0.05).Both BASDAI and ASDAScrp had negative linear correlations with Schober's test (P<0.001). Conclusion ASDAScrp has good correlation with BASDAI and is superior to BASDAI especially in respects of correlation with clinical and laboratory indexes.ASDAScrp can also reflect the degree of inflammation on MRI in sacroiliac joint.