Factors affecting pelvic lymph node metastasis and prognosis of patients undergoing radical surgery for cervical cancer

Objective To explore the factors affecting pelvic lymph node metastasis and 5-year survival rate of patients undergoing radical surgery for cervical cancer. Methods The clinical and pathological data of 225 cases of stage 1A-2B cervical cancer undergoing radical surgery in our hospital between January,2007 and December,2012 were reviewed and analyzed respectively. Results Among 225 cases of cervical cancer,there were 54 cases of lymph node metastasis with a rate of 24.0%.The patients with hemoglobin level<110 g/L before the treatment,FIGO stage Ⅱ,depth of myometrial invasion ≥ 1/2,parametrial invasion,lymph-vascular space invasion,tumor diameter ≥ 4 cm usually had high metastasis rate of lymph node when compare with the patients with the hemoglobin level ≥ 110 g/L before the treatment,FIGO stage Ⅰ,myometrial invasion<1/2,no parametrial invasion,without lymph-vascular space invasion,tumor diameter <4 cm patients (P<0.05).Hemoglobin level before the treatment,FIGO stage,parametrial invasion,lymph-vascular space invasion and tumor diameter were the independent factors of cervical lymph node metastasis (P<0.05).The 5-year survival rate of cancer patients was 83.7%.The 5-year survival of patients with age ≥ 45 years,hemoglobin level<110 g/L before treatment,FIGO stage Ⅱ,depth of myometrial invasion ≥ 1/2,parametrial invasion,lymph-vascular space invasion,tumor diameter ≥ 4 cm,non-squamous cell carcinoma and lymph node metastasis were lower than the patients with age <45 years of age,hemoglobin level ≥ 110 g/L before the treatment,FIGO stage Ⅰ,myometrial invasion<1/2,no parametrial invasion,without lymph vascular space invasion,tumor diameter <4 cm,squamous cell carcinoma,without lymph-node metastasis patients (P<0.05).Hemoglobin level before the treatment,lymphatic vascular space invasion,non-squamous cell carcinoma and lymph node metastasis were the independent predictors of 5-year survival rate of patients with cervical cancer (P<0.05). Conclusion Hemoglobin level before the treatment,FIGO stage,parametrial invasion,lymph-vascular space invasion,tumor diameter were the independent factors of cervical lymph node metastasis.Hemoglobin level before the treatment,lymphatic vascular space invasion,non-squamous cell carcinoma and lymph node metastasis were independent predictors of 5-year survival rate of patients with cervical cancer.