Effects of Shen Fu Injection on serum levels of NSE and S-100B protein and prognosis in patients with cardiac arrest after cerebral resuscitation

Objective To investigate the effect of Shen Fu Injection in the treatment of cardiac arrest (cardiac arrest,CA) in patients with cerebral resuscitation after serum neuron specific enolase (NSE) and S-100B protein,and evaluate its effect on prognosis. Methods One hundred and six cases of patients with spontaneous circulation recovery after cardiac arrest in our hospital were divided into two groups,53 cases in each group.The control group was used conventional cerebral resuscitation,maintain low body heat.On the basis of the control group,the treatment group was treated with Shen Fu injection.0.5,2,12 and 24 hours after cardiopulmonary resuscitation,the serum levels of NSE and S-100B in the two groups were detected by ELISA.12,24,48,72 hours after cardiac arrest,the changes of cerebral oxygen metabolism were detected in two groups of patients.Glasgow Coma Scale (GCS) was used to assess coma status.The recovery rate and mortality rate of the two groups were recorded. Results After cardiopulmonary resuscitation,the levels of NSE and S-100B were significantly increased in the two groups (P<0.05).The levels of NSE and S-100B in the treatment group were significantly lower than those in the control group at 2,12 hours and 24 hours after cardiopulmonary resuscitation.The difference was statistically significant (P<0.05).12,24,48 and 72 hours after cardiac arrest,two patients with arteriovenous oxygen content difference (Ca-jvO₂),cerebral oxygen uptake rate (CERO₂) decreased significantly,jugular bulb oxygen saturation (SjvO₂),GCS score increased significantly (P<0.05).Ca-jvO₂,CERO₂ and GCS scores of the treatment group were significantly higher than those in the control group at 48 hours and 72 hours after cardiac arrest.SjvO₂ was significantly lower than that in the control group.The difference was statistically significant (P<0.05).The effective rate (67.92%) in treatment group was significantly higher than that in control group (45.28%),and mortality (69.81%) was significantly lower than that in control group (88.68%).The difference was statistically significant (χ²=5.530,5.736,P<0.05). Conclusion The serum levels of NSE and S-100B in patients with cardiac arrest after cerebral resuscitation can be decreased significantly by the injection of Shen Fu injection,which is helpful to improve the prognosis of patients.